Reduced cognitive function in patients with parkinson disease and obstructive sleep apnea.

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dc.contributor.authorMery, Victoria
dc.contributor.authorGros, Priti
dc.contributor.authorLafontaine, Anne-Louise
dc.contributor.authorRobinson, Ann
dc.contributor.authorBenedetti, Andrea
dc.contributor.authorKimoff, John
dc.contributor.authorKaminska, Marta
dc.date.accessioned2017-09-12T13:40:14Z
dc.date.available2017-09-12T13:40:14Z
dc.date.issued2017
dc.description.abstractOBJECTIVE: To assess the association between obstructive sleep apnea (OSA) and nonmotor symptoms (NMS), including cognitive dysfunction, in patients with Parkinson disease (PD). METHODS: Patients with idiopathic PD, recruited from a movement disorder clinic, underwent overnight polysomnography. OSA was defined as an apnea-hypopnea index (AHI) ≥15/h. PD severity was assessed using the Hoehn & Yahr (H&Y) scale and the Movement Disorder Society Unified Parkinson's Disease Rating Scale (MDS-UPDRS). NMS were assessed using the Montreal Cognitive Assessment (MoCA), Epworth Sleepiness Scale (ESS), Fatigue Severity Scale, Apathy Scale, Beck Depression Inventory, Hospital Depression and Anxiety Scale, and PD sleep Scale. RESULTS: Sixty-seven patients (61.2% male), mean age 64.4 (SD 9.9) years and motor MDS-UPDRS 21.9 (12.6) using levodopa equivalent dose (LED) 752.4 (714.6) mg/d, were studied. OSA occurred in 47 patients (61.6%, mean AHI 27.1/h, SD 20.2/h), and NMS in 57 patients (85%). ESS and MoCA were associated with the AHI (ESS β = 0.0670, p = 0.031; MoCA β = -0.0520, p = 0.043, adjusted for age, sex, body mass index, LED, and H&Y). ESS was associated with respiratory arousals (β = 0.1015, p = 0.011) and intermittent hypoxemia (β = 0.1470, p = 0.006). MoCA was negatively associated with respiratory arousals (β = -0.0596, p = 0.049) but not intermittent hypoxemia. CONCLUSIONS: OSA is associated with sleepiness and cognitive dysfunction in PD, suggesting that OSA may be a reversible contributor to these NMS. Further studies will be required to evaluate whether OSA treatment can improve excessive sleepiness and cognitive dysfunction in PD.
dc.format.extent9
dc.identifier.citationNeurology. 2017 Mar 21;88(12):1120-1128
dc.identifier.urihttp://hdl.handle.net/11447/1679
dc.identifier.urihttp://dx.doi.org/10.1212/WNL.0000000000003738
dc.language.isoen_US
dc.publisherAmerican Academy of Neurology
dc.subjectCognition Disorders
dc.subjectParkinson Disease
dc.subjectSleep Apnea, Obstructive
dc.titleReduced cognitive function in patients with parkinson disease and obstructive sleep apnea.
dc.typeArtículo

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