Echoes of maternal childhood maltreatment: The role of a maternal genetic marker in mother-infant coregulation

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dc.contributor.advisorSilva, Jaime
dc.contributor.authorEspinoza Barría, Mauricio Fernando
dc.coverage.spatialSantiago
dc.date.accessioned2026-08-04T19:18:23Z
dc.date.available2026-08-04T19:18:23Z
dc.date.issued2026
dc.descriptionDissertation submitted to Facultad de Psicología of Universidad del Desarrollo in partial fulfillment for the academic degree of Doctor in Developmental Science & Psychopathology
dc.description.abstractChildhood maltreatment has enduring consequences for neurobiological, socioemotional, and relational development, with effects that can extend into the next generation. Guided by a gene × environment framework, this dissertation examines how maternal histories of childhood maltreatment relate to motherinfant coregulation at behavioral and physiological levels during the first year of life, and whether these associations are moderated by maternal FKBP5 genetic variation. In Study 1, conducted with Chilean dyads, the FKBP5 rs1360780 polymorphism moderated the association between maternal childhood maltreatment and behavioral mother-infant coregulation in a pattern consistent with differential susceptibility, even though no direct effects were observed. In Study 2, no evidence of effects on physiological coregulation emerged. Study 3, conducted with a U.S. sample, further demonstrated that behavioral coregulation at four months mediated the association between maternal childhood maltreatment and early-emerging psychopathology at ages two to three years. Together, these studies demonstrate the impact of maternal maltreatment on early behavioral coregulation, highlight the moderating role of FKBP5, and position behavioral coregulation as a key mechanism linking maternal early experiences to early-emerging socioemotional difficulties. These findings offer insight into intergenerational pathways of stress regulation and inform efforts to promote early relational health.
dc.format.extent202 p.
dc.identifier.doihttps://doi.org/10.52611/11447/10952
dc.identifier.urihttps://hdl.handle.net/11447/10952
dc.language.isoen
dc.publisherUniversidad del Desarrollo. Facultad de Psicología
dc.subjectDyadic co-regulation
dc.subjectChildhood maltreatment
dc.subjectDifferential susceptibility
dc.subjectGene–environment interaction
dc.titleEchoes of maternal childhood maltreatment: The role of a maternal genetic marker in mother-infant coregulation
dc.typeThesis
dcterms.accessRightsPrivado

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