Colonic content in health and its relation to functional gut symptoms

Simple item page
dc.contributor.authorBendezu, Roger
dc.contributor.authorBarba, Elizabeth
dc.contributor.authorBurri, E
dc.contributor.authorCisternas, Daniel
dc.contributor.authorAccarino, A
dc.contributor.authorQuiroga, Sergi
dc.contributor.authorMonclus, Eva
dc.contributor.authorNavazo, I
dc.contributor.authorMalagelada, J
dc.contributor.authorAzpiroz, Fernando
dc.date.accessioned2017-12-28T19:19:03Z
dc.date.available2017-12-28T19:19:03Z
dc.date.issued2016
dc.description.abstractBACKGROUND: Gut content may be determinant in the generation of digestive symptoms, particularly in patients with impaired gut function and hypersensitivity. Since the relation of intraluminal gas to symptoms is only partial, we hypothesized that non-gaseous component may play a decisive role. METHODS: Abdominal computed tomography scans were evaluated in healthy subjects during fasting and after a meal (n = 15) and in patients with functional gut disorders during basal conditions (when they were feeling well) and during an episode of abdominal distension (n = 15). Colonic content and distribution were measured by an original analysis program. KEY RESULTS: In healthy subjects both gaseous (87 ± 24 mL) and non-gaseous colonic content (714 ± 34 mL) were uniformly distributed along the colon. In the early postprandial period gas volume increased (by 46 ± 23 mL), but non-gaseous content did not, although a partial caudad displacement from the descending to the pelvic colon was observed. No differences in colonic content were detected between patients and healthy subjects. Symptoms were associated with discrete increments in gas volume. However, no consistent differences in non-gaseous content were detected in patients between asymptomatic periods and during episodes of abdominal distension. CONCLUSIONS & INFERENCES: In patients with functional gut disorders, abdominal distension is not related to changes in non-gaseous colonic content. Hence, other factors, such as intestinal hypersensitivity and poor tolerance of small increases in luminal gas may be involved.
dc.format.extent6
dc.identifier.citationBendezú RA, Barba E, Burri E, Cisternas D, Accarino A, Quiroga S, Monclus E, Navazo I, Malagelada JR, Azpiroz F. Colonic content in health and its relation to functional gut symptoms. Neurogastroenterol Motil. 2016 Jun;28(6):849-54.
dc.identifier.urihttp://hdl.handle.net/11447/1809
dc.identifier.urihttp://dx.doi.org/10.1111/nmo.12782
dc.language.isoen_US
dc.publisherJohn Wiley & Sons
dc.subjectabdominal distension
dc.subjectcolonic content
dc.subjectfood ingestion
dc.subjectfunctional gut disorders
dc.subjectintestinal gas
dc.titleColonic content in health and its relation to functional gut symptoms
dc.typeArtículo

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Colonic content in health and its relation to functional gut symptoms.pdf
Size:
2.64 MB
Format:
Adobe Portable Document Format
Description:
Texto completo
Download

Collections

Artículos Medicina y Ciencias de la Salud

Implementado por OpenGeek Services