Unmyelinated afferents in human skin and their responsiveness to low temperature

dc.contributor.author	Campero, Mario
dc.contributor.author	Bostock, Hugh
dc.date.accessioned	2021-10-25T15:33:33Z
dc.date.available	2021-10-25T15:33:33Z
dc.date.issued	2010
dc.description.abstract	In humans, there are different types of cutaneous cold-sensitive afferents responsible for cold sensation and cold pain. Innocuous cold is primarily mediated by a population of slow A delta afferents, based on psychophysical and neurophysiological studies. Noxious cold (usually below 15 ◦C) is mediated, at least in part, by polymodal nociceptors. There is also a population of unmyelinated afferents responsive to innocuous low temperature, some of which also respond to heat, whose sensory function has not been completely defined. A paradoxical hot/burning evoked by cooling is unmasked by A-fibre block, and similar sensations are evoked by applying simultaneous cool and warm stimuli to adjacent skin areas. These unmyelinated fibres activated by innocuous cooling (and heating) may contribute to this hot/burning sensation, along with other thermoregulatory functions.	es
dc.identifier.citation	Neuroscience Letters 470 (2010) 188–192	es
dc.identifier.uri	https://doi.org/10.1016/j.neulet.2009.06.089	es
dc.identifier.uri	http://hdl.handle.net/11447/4900
dc.language.iso	en_US	es
dc.subject	Cold fibres	es
dc.subject	Cold pain	es
dc.subject	Microneurography	es
dc.subject	Unmyelinated afferents	es
dc.title	Unmyelinated afferents in human skin and their responsiveness to low temperature	es
dc.type	Article	es

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