Degree and Timing of Intensive Blood Pressure Lowering on Hematoma Growth in Intracerebral Hemorrhage: Intensive Blood Pressure Reduction in Acute Cerebral Hemorrhage Trial-2 Results

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dc.contributor.authorCarcel, Cheryl
dc.contributor.authorWang, Xia
dc.contributor.authorSato, Shoichiro
dc.contributor.authorStapf, Christian
dc.contributor.authorSandset, Else
dc.contributor.authorDelcourt, Candice
dc.contributor.authorArima, Hisatomi
dc.contributor.authorThompson, Robinson
dc.contributor.authorLavados, Pablo
dc.contributor.authorChalmers, John
dc.contributor.authorAnderson, Craig
dc.contributor.authorINTERACT2 Investigators
dc.date.accessioned2017-01-04T18:59:49Z
dc.date.available2017-01-04T18:59:49Z
dc.date.issued2016
dc.description.abstractBACKGROUND AND PURPOSE: Degree and timing of blood pressure (BP) lowering treatment in relation to hematoma growth were investigated in the Intensive Blood Pressure Reduction in Acute Cerebral Hemorrhage Trial-2 (INTERACT2). METHODS: INTERACT2 was an international clinical trial of intensive (target systolic BP [SBP], <140 mm Hg) versus guideline-recommended (SBP, <180 mm Hg) BP lowering in 2839 patients within 6 hours of spontaneous intracerebral hemorrhage and elevated SBP (150-220 mm Hg), in which 964 had repeat cranial computed tomography at 24 hours. ANCOVA models assessed categories of SBP reduction and time to target SBP on 24-hour hematoma growth. RESULTS: Greater SBP reduction was associated with reduced hematoma growth (13.3, 5.0, and 3.0 mL for <10, 10-20, and ≥20 mm Hg, respectively; P trend<0.001). In the intensive treatment group (n=491), the least mean hematoma growth was in patients who achieved target SBP <1 hour (2.6 mL) versus to those in target at 1 to 6 (4.7 mL) and >6 hours (5.4 mL). The smallest mean absolute hematoma growth (2.0 mL) was in those achieving target SBP 5 to 8 times versus 3 to 4 (3.1 mL) and 0 to 2 times (5.2 mL). CONCLUSIONS: Intensive BP lowering with greater SBP reduction, which is achieved quickly and maintained consistently, seems to provide protection against hematoma growth for 24 hours. CLINICAL TRIAL REGISTRATION: URL: http://www.clinicaltrials.gov. Unique identifier: NCT00716079
dc.identifier.citationCarcel C, Wang X, Sato S, Stapf C, Sandset EC, Delcourt C, Arima H, Robinson T, Lavados P, Chalmers J, Anderson CS; INTERACT2 Investigators*. Degree and Timing of Intensive Blood Pressure Lowering on Hematoma Growth in Intracerebral Hemorrhage: Intensive Blood Pressure Reduction in Acute Cerebral Hemorrhage Trial-2 Results. Stroke. 2016 Jun;47(6):1651-3.
dc.identifier.urihttp://hdl.handle.net/11447/928
dc.identifier.urihttp://dx.doi.org/ 10.1161/STROKEAHA.116.013326
dc.language.isoen_US
dc.publisherAmerican Heart Association, Inc.
dc.subjectBlood pressure
dc.subjectCerebral hemorrhage
dc.subjectHematoma
dc.subjectTomography
dc.titleDegree and Timing of Intensive Blood Pressure Lowering on Hematoma Growth in Intracerebral Hemorrhage: Intensive Blood Pressure Reduction in Acute Cerebral Hemorrhage Trial-2 Results
dc.typeArtículo

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