Longitudinal assessment of SARS-CoV-2 IgG seroconversionamong front-line healthcare workers during the first wave of the Covid 19 pandemic at a tertiary-care hospital in Chile

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dc.contributor.authorIruretagoyena, Mirentxu
dc.contributor.authorVial, Macarena
dc.contributor.authorSpencer-Sandino, Maria
dc.contributor.authorGaete, Pablo
dc.contributor.authorPeters, Anne
dc.contributor.authorDelgado, Iris
dc.contributor.authorPerez, Inia
dc.contributor.authorCalderón, Claudia
dc.contributor.authorPorte, Lorena
dc.contributor.authorLegarraga, Paulette
dc.contributor.authorAnderson, Alicia
dc.contributor.authorAguilera, Ximena
dc.contributor.authorVial, Pablo
dc.contributor.authorWeitzel, Thomas
dc.contributor.authorMunita, José
dc.date.accessioned2021-12-06T19:13:26Z
dc.date.available2021-12-06T19:13:26Z
dc.date.issued2021
dc.description.abstractBackground: Healthcare workers (HCWs) are at high risk of exposure to SARS-CoV-2. Cross-sectional studies have provided variable rates of seroprevalence in HCWs. Longitudinal assessments of the serological response to Covid 19 among HCWs are crucial to understanding the risk of infection and changes in antibody titers over time. We aimed to investigate seroprevalence and risk factors associated with seroconversion in a prospective cohort of HCWs during the peak of the first wave of the Covid-19 pandemic. Methods: We conducted a longitudinal study among 446 front-line HCWsin a tertiary-care hospital in Chile from April to July 2020. IgG was determined monthly using two different ELISAs in serum samples of HCWs, during the three-month period. In each visit, demographic data, symptoms, risk factors, and exposure risks were also assessed. Results: The overall seroprevalence at the end of the study period was 24% (95% CI20.2–28.3), with 43% of seropositive HCWs reporting no prior symptoms. Seroconversion rates significantly differed over the study period, from 2.1% to as high as 8.8% at the peak of the epidemic. There were no statistically significant differences observed between HCWs in direct clinical care of patients with Covid-19 and those working in low risk areas. Antibody titers appeared to wane over time. Conclusions: HCWs were severely affected with a high rate of seroconversion that appeared to mirror the local epidemiological situation. A significant amount of participants underwent an asymptomatic infection, highlighting the need for improved surveillance policies. Antibody titers appear to wane over time; further studies to understand this finding’s impact on the risk of reinfection are warrantedes
dc.identifier.citationIruretagoyena M, Vial MR, Spencer-Sandino M, Gaete P, Peters A, Delgado I, Perez I, Calderon C, Porte L, Legarraga P, Anderson A, Aguilera X, Vial P, Weitzel T, Munita JM. Longitudinal assessment of SARS-CoV-2 IgG seroconversionamong front-line healthcare workers during the first wave of the Covid-19 pandemic at a tertiary-care hospital in Chile. BMC Infect Dis. 2021 May 26;21(1):478. doi: 10.1186/s12879-021-06208-2es
dc.identifier.urihttp://hdl.handle.net/11447/5189
dc.identifier.urihttps://doi.org/10.1186/s12879-021-06208-2
dc.language.isoenes
dc.subjectCovid-19es
dc.subjectSARS-CoV-2es
dc.subjectSeroprevalencees
dc.subjectSeroconversiones
dc.subjectHealthcare workerses
dc.titleLongitudinal assessment of SARS-CoV-2 IgG seroconversionamong front-line healthcare workers during the first wave of the Covid 19 pandemic at a tertiary-care hospital in Chilees
dc.typeArticlees
dcterms.sourceBMC Infectious Diseaseses

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