The Role of Colchicine in Atherosclerosis: From Bench to Bedside

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dc.contributor.authorGonzález, Leticia
dc.contributor.authorBulnes, Juan
dc.contributor.authorOrellana, María
dc.contributor.authorMuñoz, Paula
dc.contributor.authorMartínez, Gonzalo
dc.date.accessioned2022-11-21T18:53:52Z
dc.date.available2022-11-21T18:53:52Z
dc.date.issued2022
dc.description.abstractInflammation is a key feature of atherosclerosis. The inflammatory process is involved in all stages of disease progression, from the early formation of plaque to its instability and disruption, leading to clinical events. This strongly suggests that the use of anti-inflammatory agents might improve both atherosclerosis progression and cardiovascular outcomes. Colchicine, an alkaloid derived from the flower Colchicum autumnale, has been used for years in the treatment of inflammatory pathologies, including Gout, Mediterranean Fever, and Pericarditis. Colchicine is known to act over microtubules, inducing depolymerization, and over the NLRP3 inflammasome, which might explain its known anti-inflammatory properties. Recent evidence has shown the therapeutic potential of colchicine in the management of atherosclerosis and its complications, with limited adverse effects. In this review, we summarize the current knowledge regarding colchicine mechanisms of action and pharmacokinetics, as well as the available evidence on the use of colchicine for the treatment of coronary artery disease, covering basic, translational, and clinical studies.es
dc.description.versionVersión publicadaes
dc.identifier.citation: González, L.; Bulnes, J.F.; Orellana, M.P.; Muñoz Venturelli, P.; Martínez Rodriguez, G. The Role of Colchicine in Atherosclerosis: From Bench to Bedside. Pharmaceutics 2022, 14, 1395. https://doi.org/10.3390/ pharmaceutics14071395es
dc.identifier.urihttps://doi.org/10.3390/pharmaceutics14071395es
dc.identifier.urihttp://hdl.handle.net/11447/6707
dc.language.isoenes
dc.subjectAtherosclerosises
dc.subjectInflammationes
dc.subjectColchicinees
dc.subjectNLRP3 inflammasomees
dc.subjectCoronary artery diseasees
dc.subjectAcute coronary syndromees
dc.titleThe Role of Colchicine in Atherosclerosis: From Bench to Bedsidees
dc.typeArticlees
dcterms.sourcePharmaceuticses

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