Predictive Model for Response Rate to Narrowband Ultraviolet B Phototherapy in Vitiligo: A Retrospective Cohort Study of 579 Patients
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Date
2018
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Article
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Abstract
Vitiligo is an acquired depigmenting disorder. To date, there is no predictive model for its response rate to narrowband ultraviolet B (NBUVB) phototherapy. The aim of this study was to investigate the different types of response of patients with non-segmental vitiligo undergoing NBUVB 3 times a week. Many patients who were previously considered non-responders were given the opportunity to continue the treatment. Longterm maintenance of treatment and follow-up of a cohort of 579 patients enabled different subtypes of
response (very rapid, rapid, average, slow and “nonresponders”) to be described for the first time, and a predictive model of response to be constructed based on repigmentation rate in the first 48 sessions of NBUVB. Among those patients who did not respond
during the first 48 sessions, a new subgroup of patients was found, termed “very-slow” responders, who achieved a low, but significant, level of repigmentation after 96 sessions of NBUVB.
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Citation
Cabrera R, Hojman L, Recule F, Sepulveda R, Delgado I. Predictive Model for Response Rate to Narrowband Ultraviolet B Phototherapy in Vitiligo: A Retrospective Cohort Study of 579 Patients. Acta Derm Venereol. 2018 Apr 16;98(4):416-420. doi: 10.2340/00015555-2889.
Keywords
Vitiligo, Phototherapy, Ultraviolet, Narrowband UVB, Predictive model