Use of N-acetylcysteine plus simethicone to improve mucosal visibility during upper GI endoscopy: a double-blind, randomized controlled trial

Simple item page
dc.contributor.authorMonrroy, Hugo
dc.contributor.authorVargas, José
dc.contributor.authorGlasinovic, Esteban
dc.contributor.authorCandia, Roberto
dc.contributor.authorAzúa, Emilio
dc.contributor.authorGálvez, Camila
dc.contributor.authorCabrera, Natalia
dc.contributor.authorVidaurre, Josefa
dc.contributor.authorÁlvarez, Natalia
dc.contributor.authorGonzález, Jessica
dc.contributor.authorEspino, Alberto
dc.contributor.authorGonzález, Robinson
dc.contributor.authorParra, Adolfo
dc.date.accessioned2022-06-02T19:00:57Z
dc.date.available2022-06-02T19:00:57Z
dc.date.issued2018
dc.description.abstractBackground and aim: Upper GI endoscopy (UGE) is essential for the diagnosis of gastrointestinal diseases. Mucus and bubbles may decrease mucosal visibility. The use of mucolytics could improve visualization. Our aim was to determine whether premedication with simethicone or simethicone plus N-acetylcysteine is effective in improving visibility during UGE. Methods: This was a randomized, double-blinded, placebo-controlled trial with 2 control groups: no intervention and water 100 mL (W); and 3 intervention groups: simethicone 200 mg (S); S + N-acetylcysteine (NAC) 500 mg (S+NAC500); and S + NAC 1000 mg (S+NAC1000). The solution was ingested 20 minutes before UGE. Gastric visibility was evaluated in 4 segments with a previously described scale. A score of less than 7 points was defined as adequate visibility (AV). Water volume was used to improve visibility, and adverse reactions were evaluated as a secondary outcome. Multiple group comparison was performed using non-parametric one-way analysis of variance (ANOVA). Results: Two hundred thirty patients were included in the study, 68% female, mean age 49 years. The most common indication for UGE was epigastric pain/dyspepsia (33%). AV was more frequent in the S+NAC500 and S+NAC1000 groups (65% and 67%) compared with no intervention (44%, P = .044) and water (41%, P = .022). The gastric total visibility scale (TVS) was significantly better in the S+NAC500 and S+NAC1000 groups compared with water (P = .03 and P = .008). Simethicone was not different from no intervention and water. S+NAC1000 required less water volume to improve visibility. No adverse reactions from the study drugs were observed. Conclusions: Premedication with S+NAC500 and S+NAC1000 improves visibility during UGE. The use of simethicone did not show improvements in gastric visibility. TVS was worse in patients using water alone. (Clinical trial registration number: NCT 01653171.).es
dc.description.versionVersión publicadaes
dc.identifier.citationMonrroy H, Vargas JI, Glasinovic E, Candia R, Azúa E, Gálvez C, Rojas C, Cabrera N, Vidaurre J, Álvarez N, González J, Espino A, González R, Parra-Blanco A. Use of N-acetylcysteine plus simethicone to improve mucosal visibility during upper GI endoscopy: a double-blind, randomized controlled trial. Gastrointest Endosc. 2018 Apr;87(4):986-993. doi: 10.1016/j.gie.2017.10.005es
dc.identifier.urihttps://doi.org/10.1016/j.gie.2017.10.005es
dc.identifier.urihttp://hdl.handle.net/11447/6180
dc.language.isoenes
dc.subjectAcetylcysteine / administration & dosagees
dc.subjectAntifoaming Agents / administration & dosagees
dc.subjectEndoscopy, Gastrointestinal / methodses
dc.subjectExpectorants / administration & dosagees
dc.subjectGastric Mucosa / diagnostic imaginges
dc.subjectSimethicone / administration & dosagees
dc.subjectSimethiconees
dc.subjectStomach Diseases / diagnostic imaginges
dc.subjectWater / administration & dosagees
dc.subjectDouble-Blind Methodes
dc.subjectAged, 80 and overes
dc.titleUse of N-acetylcysteine plus simethicone to improve mucosal visibility during upper GI endoscopy: a double-blind, randomized controlled triales
dc.typeArticlees
dcterms.sourceGastrointestinal endoscopyes

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
1-s2.0-S0016510717323544-main.pdf
Size:
1.13 MB
Format:
Adobe Portable Document Format
Description:
Texto completo
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Artículos Medicina y Ciencias de la Salud

Implementado por OpenGeek Services