Características clínicas y factores pronósticos de la enfermedad meningocóccica: un estudio de serie de casos en Chile durante el brote 2012-2013

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dc.contributor.authorMatute, Isabel
dc.contributor.authorOlea, Andrea
dc.contributor.authorLópez, Darío
dc.contributor.authorLoayza, Sergio
dc.contributor.authorNájera, Manuel
dc.contributor.authorGonzález, Claudia
dc.contributor.authorPoffald, Lucy
dc.contributor.authorHirmas, Macarena
dc.contributor.authorDelgado, Iris
dc.contributor.authorPedroni, Elena
dc.contributor.authorAlfaro, Tania
dc.contributor.authorGormaz, Ana María
dc.contributor.authorSanhueza, Gabriel
dc.contributor.authorVial, Pablo
dc.contributor.authorDabanch, Jeannette
dc.contributor.authorGallegos, Doris
dc.contributor.authorAguilera, Ximena
dc.date.accessioned2016-05-16T18:50:14Z
dc.date.available2016-05-16T18:50:14Z
dc.date.issued2015
dc.description.abstractIntroduction: Meningococcal disease (MD) is a major global problem because of its case fatality rate and sequels. Since 2012 cases of serogroup W have increased in Chile, with nonspecific clinical presentation, high case fatality rate and serious consequences. Objective: To characterize the evolution and outcome of MD cases between January 2012 and March 2013 in Chile. Material and Methods: Case series considering149 MD cases of 7 regions. A questionnaire was applied and clinical records were reviewed, including individual, agent, clinical course and healthcare process variables. The analysis allowed to obtain estimates of the OR as likelihoodof dying. Results: 51.5% was meningococcemia, the case fatality rate reached 27%, prevailing serogroup W (46.6%). Factors that increased the probability of dying: > age, belonging to indigenous people, having lived a stressful event, having diarrhea, impaired consciousness, cardiovascular symptoms, low oxygen saturation and low Glasgow coma scale score. Discussion: The case fatality rate exceeded normal levels and was higher in serogroup W. Increasing in this serogroup, associated to the increased presence of nonspecific symptoms or rapid progression to septicemia, hit a health system accustomed to more classic meningococcal disease presentation, which could partly explain the observed increased fatality rate.
dc.identifier.citationMatute, Isabel, Olea, Andrea, López, Darío, Loayza, Sergio, Nájera, Manuel, González, Claudia, Poffald, Lucy, Hirmas, Macarena, Delgado, Iris, Pedroni, Elena, Alfaro, Tania, Gormaz, Ana María, Sanhueza, Gabriel, Vial, Pablo, Dabanch, Jeannette, Gallegos, Doris, & Aguilera, Ximena. (2015). Características clínicas y factores pronósticos de la enfermedad meningocóccica: un estudio de serie de casos en Chile durante el brote 2012-2013. Revista chilena de infectología, 32(5), 505-516.
dc.identifier.urihttp://hdl.handle.net/11447/256
dc.identifier.urihttp://dx.doi.org/10.4067/S0716-10182015000600003
dc.language.isospa
dc.publisherSociedad Chilena de Infectología
dc.subjectMeningococcal disease
dc.subjectSerogroup
dc.subjectCase fatality rate
dc.titleCaracterísticas clínicas y factores pronósticos de la enfermedad meningocóccica: un estudio de serie de casos en Chile durante el brote 2012-2013
dc.title.alternativeClinical features and prognostic factors of meningococcal disease: a case series study in Chile during the 2012-2013 outbreak
dc.typeArtículo

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