Effect of Thyromimetic GC-1 Selective Signaling on Reproductive and Lactational Performance in the Hypothyroid Rat

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dc.contributor.authorRinaldini, Estefanía
dc.contributor.authorCampo Verde, Fiorella
dc.contributor.authorEzquer, Marcelo
dc.contributor.authorGamarra, Carlos
dc.contributor.authorHapon, María Belén
dc.date.accessioned2022-03-10T14:33:09Z
dc.date.available2022-03-10T14:33:09Z
dc.date.issued2020
dc.description.abstractIntroduction: The potential of the thyroid hormone receptor β (TRβ1) selective analog GC-1 has been widely proven in animal models and humans. However, its effect on the reproductive stage of the female rat has not been evaluated. Methods: The effect of the administration of GC-1 or equimolar doses of triiodothyronine (T3) was evaluated on the reproductive performance of the hypothyroid female rat and the indirect effect on pup thyroid status, weight, and survival. Results: Hypothyroidism reduced the number of embryos implanted in the uterus, whereas T3 and GC-1 treatment in hypothyroid females reestablished the number of implanted embryos to normal. Initiation of labor was delayed by hypothyroidism, and T3 replacement treatment reinstated the normal timing of parturition. The administration of GC-1 alone to the lactating mother did not affect pup survival, weight, or thyroidal status. Conclusions: Our findings show the differential effect of thyroid hormone selective signaling during gestation and the indirect exposure of the pups; we also emphasize the plausible use of GC-1 for treatment of hypothyroid mothers during the lactation period.es
dc.description.versionVersión publicadaes
dc.identifier.citationRinaldini E, Verde Arboccó FC, Ezquer M, Gamarra-Luques C, Hapon MB. Effect of Thyromimetic GC-1 Selective Signaling on Reproductive and Lactational Performance in the Hypothyroid Rat. Eur Thyroid J. 2021 Jul;10(5):425-433. doi: 10.1159/000516432es
dc.identifier.urihttps://doi.org/10.1159/000516432es
dc.identifier.urihttp://hdl.handle.net/11447/5688
dc.language.isoenes
dc.subjectHypothyroidismes
dc.subjectPup survivales
dc.subjectLactationes
dc.subjectGestationes
dc.subjectGC-1es
dc.titleEffect of Thyromimetic GC-1 Selective Signaling on Reproductive and Lactational Performance in the Hypothyroid Rates
dc.typeArticlees
dcterms.sourceEuropean thyroid journales

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