Reactivity of benzohydrazide derivatives towards acetylation reaction. Experimental and theoretical studies

dc.contributor.author	Campodónico, Paola
dc.contributor.author	Aliaga, Margarita E.
dc.contributor.author	Santos, José G.
dc.contributor.author	Castro, Enrique A.
dc.contributor.author	Contreras, Renato
dc.date.accessioned	2021-10-25T14:51:20Z
dc.date.available	2021-10-25T14:51:20Z
dc.date.issued	2010
dc.description.abstract	We herein report an experimental and theoretical study on the acetylation reaction of benzohydrazide derivatives towards p-nitrophenyl acetate (NPA). The kinetic data are consistent with a stepwise mechanism with the nucleophilic attack as the rate determining step. From the theoretical analysis it is found that benzohydrazide derivatives establish intramolecular proton rearrangement. The enol form appears as the active species for nucleophilic attack. A reaction mechanism incorporating keto-enol pre-equilibria is proposed. The study is completed with a local reactivity analysis describing the most reactive centers for nucleophilic attack together with a site activation analysis describing inductive substituent effect	es
dc.identifier.citation	Chemical Physics Letters 488 (2010) 86–89	es
dc.identifier.uri	http://hdl.handle.net/11447/4895
dc.language.iso	en_US	es
dc.title	Reactivity of benzohydrazide derivatives towards acetylation reaction. Experimental and theoretical studies	es
dc.type	Article	es

Files

Now showing 1 - 1 of 1

Name:: Reactivity of benzohydrazide derivatives towards acetylation reaction..pdf
Size:: 358.42 KB
Format:: Adobe Portable Document Format
Description:: Texto Completo

Now showing 1 - 1 of 1