Switching stable kidney transplant recipients to a generic tacrolimus Is feasible and safe, but it must be monitored

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dc.contributor.authorGonzález, Fernando
dc.contributor.authorLópez, René
dc.contributor.authorArriagada, Elizabeth
dc.contributor.authorCarrasco, René
dc.contributor.authorGallardo, Natalia
dc.contributor.authorLorca, Eduardo
dc.date.accessioned2018-01-17T12:50:12Z
dc.date.available2018-01-17T12:50:12Z
dc.date.issued2017
dc.description.abstractBackground. Tacrolimus is the primary immunosuppressive drug used in kidney transplant patients. Replacing brand name products with generics is a controversial issue that we studied after a Chilean Ministry of Health mandate to implement such a switch. Methods. Forty-one stable Prograf (Astellas) receiving kidney transplant patients were switched to a generic tacrolimus (Sandoz) in a 1 : 1 dose ratio and were followed up for up to 8 months. All other drugs were maintained as per normal practice. Results. Neither tacrolimus doses nor their trough blood levels changed significantly after the switch, but serum creatinine did: 1.62 ± 0.90 versus 1.75 ± 0.92 mg/dL (p < 0.001). At the same time, five graft biopsies were performed, and two of them showed cellular acute rejection. There were nine infectious episodes treated satisfactorily with proper therapies. No patient or graft was lost during the follow-up time period. Conclusion. Switching from brand name tacrolimus to a generic tacrolimus (Sandoz) is feasible and appears to be safe, but it must be monitored carefully by treating physicians.
dc.description.versionVersión Publicada
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dc.identifier.citationGonzález F, López R, Arriagada E, Carrasco R, Gallardo N, Lorca E. Switching Stable Kidney Transplant Recipients to a Generic Tacrolimus Is Feasible and Safe, but It Must Be Monitored. J Transplant. 2017;2017:5646858. doi: 10.1155/2017/5646858.
dc.identifier.urihttp://hdl.handle.net/11447/1910
dc.identifier.urihttps://doi.org/10.1155/2017/5646858
dc.language.isoen_US
dc.publisherHindawi Publishing Corp.
dc.sourceJournal of Transplantation
dc.subjectKidney Transplant Recipients
dc.subjectGeneric Tacrolimus
dc.subjectSwitch drugs
dc.titleSwitching stable kidney transplant recipients to a generic tacrolimus Is feasible and safe, but it must be monitored
dc.typeArtículo

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