Breakthrough bacteremia due to clostridium tertium in a patient with neutropenic fever, and identification by MALDI-TOF mass spectrometry.

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dc.contributor.authorSalvador, Francisco
dc.contributor.authorPorte, Lorena
dc.contributor.authorDuran, Luisa
dc.contributor.authorMarcotti, Alejandra
dc.contributor.authorPérez, Jorge
dc.contributor.authorThompson, Luis
dc.contributor.authorNoriega, Luis
dc.contributor.authorLois, Vivianne
dc.contributor.authorWeitzel, Thomas
dc.date.accessioned2017-04-18T14:40:38Z
dc.date.available2017-04-18T14:40:38Z
dc.date.issued2013
dc.description.abstractClostridium tertium is rare in a human clinical specimen and its pathogenicity is often uncertain. However, the organism has been increasingly recognized as a cause of bacteremia and other infections in immunocompromised patients, especially those with hematologic malignancies. The diagnosis and treatment of C. tertium are difficult due to its growth pattern, micromorphology, and antibiotic resistance. The organism can easily be misidentified as Gram-positive aerobic rods such as Bacillus species, usually considered as a contaminant. Furthermore, it is not covered by empirical treatment with many broad-spectrum antibiotics. Here we report a case of breakthrough bacteremia due to C. tertium that occurred in a patient with acute leukemia and neutropenic fever, who was treated with an empirical regimen of ceftazidime and amikacin. The bacterium was rapidly identified by new mass spectrometry technology (MALDI-TOF MS) and the patient recovered under meropenem and vancomycin treatment, without complications.
dc.format.extent2
dc.identifier.citationInternational Journal of Infectious Diseases, 2013, 17(11):e1062-3
dc.identifier.urihttp://hdl.handle.net/11447/1169
dc.identifier.urihttp://dx.doi.org/10.1016/j.ijid.2013.03.005
dc.language.isoen_US
dc.publisherElsevier
dc.subjectAntibiotic resistance
dc.subjectBacteremia
dc.subjectClostridium tertium
dc.subjectMass spectrometry
dc.subjectNeutropenia
dc.titleBreakthrough bacteremia due to clostridium tertium in a patient with neutropenic fever, and identification by MALDI-TOF mass spectrometry.
dc.typeArtículo

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