Role of ROS/RNS in Preeclampsia: Are Connexins the Missing Piece?

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dc.contributor.authorRozas, M. Fernanda
dc.contributor.authorCasanello, Paola
dc.contributor.authorRetamal, Mauricio
dc.date.accessioned2021-07-14T16:28:47Z
dc.date.available2021-07-14T16:28:47Z
dc.date.issued2020
dc.description.abstractPreeclampsia is a pregnancy complication that appears after 20 weeks of gestation and is characterized by hypertension and proteinuria, affecting both mother and offspring. The cellular and molecular mechanisms that cause the development of preeclampsia are poorly understood. An important feature of preeclampsia is an increase in oxygen and nitrogen derived free radicals (reactive oxygen species/reactive nitrogen species (ROS/RNS), which seem to be central players setting the development and progression of preeclampsia. Cell-to-cell communication may be disrupted as well. Connexins (Cxs), a family of transmembrane proteins that form hemichannels and gap junction channels (GJCs), are essential in paracrine and autocrine cell communication, allowing the movement of signaling molecules between cells as well as between the cytoplasm and the extracellular media. GJCs and hemichannels are fundamental for communication between endothelial and smooth muscle cells and, therefore, in the control of vascular contraction and relaxation. In systemic vasculature, the activity of GJCs and hemichannels is modulated by ROS and RNS. Cxs participate in the development of the placenta and are expressed in placental vasculature. However, it is unknown whether Cxs are modulated by ROS/RNS in the placenta, or whether this potential modulation contributes to the pathogenesis of preeclampsia. Our review addresses the possible role of Cxs in preeclampsia, and the plausible modulation of Cxs-formed channels by ROS and RNS. We suggest these factors may contribute to the development of preeclampsia.es
dc.format.extent19 p.es
dc.identifier.citationInternational Journal of Molecular Sciences 2020 Jun 30;21(13):4698es
dc.identifier.urihttps://doi.org/10.3390/ijms21134698es
dc.identifier.urihttp://hdl.handle.net/11447/4182
dc.language.isoenes
dc.subjectConnexinses
dc.subjectFree radicalses
dc.subjectGap junction channelses
dc.subjectHemichannelses
dc.subjectPreeclampsiaes
dc.subjectVasculaturees
dc.titleRole of ROS/RNS in Preeclampsia: Are Connexins the Missing Piece?es
dc.typeArticlees

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