Abnormal nodal and global network organization in resting state functional MRI from subjects with the 22q11 deletion syndrome

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dc.contributor.authorPelgrim, Teuntje A.D.
dc.contributor.authorBosson, Matthijs G.
dc.contributor.authorCuiza, Analía
dc.contributor.authorAlliende, Luz María
dc.contributor.authorMena, Carlos
dc.contributor.authorTepper, Angeles
dc.contributor.authorRamirez‑Mahaluf, Juan Pablo
dc.contributor.authorIruretagoyena, Bárbara
dc.contributor.authorOrnstein, Claudia
dc.contributor.authorFritsch, Rosemarie
dc.contributor.authorCruz, Juan Pablo
dc.contributor.authorTejos, Cristian
dc.contributor.authorRepetto, Gabriela
dc.contributor.authorCrossley, Nicolás
dc.date.accessioned2021-12-28T14:48:27Z
dc.date.available2021-12-28T14:48:27Z
dc.date.issued2021
dc.description.abstractThe 22q11 deletion syndrome is a genetic disorder associated with a high risk of developing psychosis, and is therefore considered a neurodevelopmental model for studying the pathogenesis of schizophrenia. Studies have shown that localized abnormal functional brain connectivity is present in 22q11 deletion syndrome like in schizophrenia. However, it is less clear whether these abnormal cortical interactions lead to global or regional network disorganization as seen in schizophrenia. We analyzed from a graph-theory perspective fMRI data from 40 22q11 deletion syndrome patients and 67 healthy controls, and reconstructed functional networks from 105 brain regions. Between-group differences were examined by evaluating edge-wise strength and graph theoretical metrics of local (weighted degree, nodal efficiency, nodal local efficiency) and global topological properties (modularity, local and global efficiency). Connectivity strength was globally reduced in patients, driven by a large network comprising 147 reduced connections. The 22q11 deletion syndrome network presented with abnormal local topological properties, with decreased local efficiency and reductions in weighted degree particularly in hub nodes. We found evidence for abnormal integration but intact segregation of the 22q11 deletion syndrome network. Results suggest that 22q11 deletion syndrome patients present with similar aberrant local network organization as seen in schizophrenia, and this network configuration might represent a vulnerability factor to psychosis.es
dc.identifier.citationPelgrim, T.A.D., Bossong, M.G., Cuiza, A. et al. Abnormal nodal and global network organization in resting state functional MRI from subjects with the 22q11 deletion syndrome. Sci Rep 11, 21623 (2021). https://doi.org/10.1038/s41598-021-00873-8es
dc.identifier.urihttps://doi.org/10.1038/s41598-021-00873-8es
dc.identifier.urihttp://hdl.handle.net/11447/5294
dc.language.isoenes
dc.subject22q11 deletion syndromees
dc.subjectBraines
dc.subjectMagnetic Resonance Imaginges
dc.subjectSchizophreniaes
dc.subjectPsychotic disorderes
dc.subjectInborn genetic diseaseses
dc.titleAbnormal nodal and global network organization in resting state functional MRI from subjects with the 22q11 deletion syndromees
dc.typeArticlees
dcterms.sourceScientific Reportses

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