Transcription-Coupled Repair Promotes the Retention of Mutations in Coding Regions During Replication Stress

Zambrano, Evelyn; Fierro, Cristopher; Morales, Fernanda; Manterola, Marcia; Marin, Arnaldo; Armisen, Ricardo; Marcelain, Katherine

Publication:
Transcription-Coupled Repair Promotes the Retention of Mutations in Coding Regions During Replication Stress

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Transcription-Coupled Repair Promotes the Retention of.pdf (5.63 MB)

Date

2026

Type:

Article

Collections

Artículos Medicina y Ciencias de la Salud

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7

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5

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Authors

Zambrano, Evelyn

Fierro, Cristopher

Morales, Fernanda

Manterola, Marcia

Marin, Arnaldo

Armisen, Ricardo

Marcelain, Katherine

item.page.doiurl

https://doi.org/10.3390/ijms27031154

URI

https://hdl.handle.net/11447/10580

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Acceso Abierto

Abstract

Replication stress (RS) is a primary driver of genomic instability in cancer, yet the contribution of transcription-coupled repair (TC-NER) to this process remains unclear. Here, we investigate how th...

Citation

Zambrano E, Fierro C, Morales F, et al. Transcription-Coupled Repair Promotes the Retention of Mutations in Coding Regions During Replication Stress. Int J Mol Sci. 2026;27(3):1154. Published 2026 Jan 23. doi:10.3390/ijms27031154

Keywords

ERCC6 (CSB) , Genomic instability , Mutagenesis , Replication stress , Transcription-coupled nucleotide excision repair (TC-NER)

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