Mesenchymal stem cell therapy for doxorubicin cardiomyopathy: hopes and fears

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dc.contributor.authorEzquer, Fernando
dc.contributor.authorGutiérrez, Jaime
dc.contributor.authorEzquer, Marcelo
dc.contributor.authorCaglevic, Christian
dc.contributor.authorSalgado, Helio
dc.contributor.authorCalligaris, Sebastián
dc.date.accessioned2016-08-02T19:01:59Z
dc.date.available2016-08-02T19:01:59Z
dc.date.issued2015
dc.descriptionCentro de Medicina Regenerativa
dc.description.abstractChemotherapy has made an essential contribution to cancer treatment in recent decades despite its adverse effects. As cancer survivors have increased, concern about ex-patient lifespan has become more important too. Doxorubicin is an effective anti-neoplastic drug that produces a cardiotoxic effect. Cancer survivors who received doxorubicin became more vulnerable to cardiac disease than the normal population did. Many efforts have been made to prevent cardiac toxicity in patients with cancer. However, current therapies cannot guarantee permanent cardiac protection. One of their main limitations is that they do not promote myocardium regeneration. In this review, we summarize and discuss the promising use of mesenchymal stem cells for cardio-protection or cardio-regeneration therapies and consider their regenerative potential without leaving aside their controversial effects on tumor progression.
dc.identifier.citationStem Cell Research & Teraphy, June 2015,vol.6, n°1, p.116
dc.identifier.urihttp://hdl.handle.net/11447/718
dc.identifier.urihttp://dx.doi.org/10.1186/s13287-015-0109-y
dc.language.isoen_US
dc.publisherBiomed Central Ltd.
dc.subjectCardiomyopathy
dc.subjectStem cell therapy
dc.subjectDoxorubicin
dc.subjectCancer
dc.subjectTumor
dc.titleMesenchymal stem cell therapy for doxorubicin cardiomyopathy: hopes and fears
dc.typeArtículo

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