Clinical Outcome and Histological Findings After Induced Leakage of PMMA Loaded With Methotrexate and Cisplatin During Vertebroplasty: Experimental Model in Pigs

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dc.contributor.authorSilva, Álvaro
dc.contributor.authorLlombart, Rafael
dc.contributor.authorGallegos, Marcela
dc.contributor.authorVillas, Carlos
dc.contributor.authorOlmos, Matías
dc.date.accessioned2022-04-01T16:09:36Z
dc.date.available2022-04-01T16:09:36Z
dc.date.issued2021
dc.description.abstractStudy design: Animal experimental model. Objective: To study the clinical behavior and histological changes in the spinal cord, nerve roots and perivertebral muscles of the spine after induced leakage of polymethylmethacrylate (PMMA) loaded with antiblastic drugs during vertebroplasty in an animal model of pigs. Methods: We performed vertebroplasty on 25 pigs. The animals were divided into 3 groups: vertebroplasty with PMMA alone (control group), vertebroplasty with PMMA loaded with methotrexate (MTX) and vertebroplasty with PMMA loaded with cisplatin (CYS). At 2 vertebral levels, epidural and prevertebral, massive cement leaks were induced. Animals were evaluated daily. Two weeks later, the pigs were sacrificed, and the tissues that came in contact with the cement were analyzed. Results: The clinical results for each of the groups were reported. The control group had no clinical alterations. In the MTX group, 2 pigs died before 1 week due to pneumonitis. In the CYS group, 4 animals had motor impairment, and 3 of the 4 had paraplegia. The histological results were as follows: the control and MTX groups showed synovial metaplasia, inflammatory reaction, crystal deposits, and giant cell reaction in the dura mater and muscle and all the animals in the CYS group had spinal cord and muscular necrosis. Conclusions: Massive cement leak after vertebroplasty with PMMA loaded with cisplatin is extremely toxic to the spinal cord and muscles around the spine. Therefore, its use cannot be recommended for the treatment of vertebral metastases. Using PMMA loaded with methotrexate seems to be a safe procedure, but further research is needed.es
dc.description.versionVersión publicadaes
dc.identifier.citationGonzález AS, Llombart-Blanco R, Angulo MG, Tomé CV, Olmos-García MA. Clinical Outcome and Histological Findings After Induced Leakage of PMMA Loaded With Methotrexate and Cisplatin During Vertebroplasty: Experimental Model in Pigs. Global Spine J. 2021 Feb 19:2192568221994800. doi:10.1177/2192568221994800es
dc.identifier.urihttps://doi.org/10.1177/2192568221994800es
dc.identifier.urihttp://hdl.handle.net/11447/5894
dc.language.isoenes
dc.sourceGlobal Spine Journal
dc.subjectAcrylic cementes
dc.subjectCisplatines
dc.subjectLeakages
dc.subjectMethotrexatees
dc.subjectVertebroplastyes
dc.titleClinical Outcome and Histological Findings After Induced Leakage of PMMA Loaded With Methotrexate and Cisplatin During Vertebroplasty: Experimental Model in Pigses
dc.typeArticlees

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