Genomic analysis of the diversity, antimicrobial resistance and virulence potential of clinical Campylobacter jejuni and Campylobacter coli strains from Chile

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dc.contributor.authorBravo, Verónica
dc.contributor.authorKatz, Assaf
dc.contributor.authorPorte, Lorena
dc.contributor.authorWeitze, Thomas
dc.contributor.authorVarela, Carmen
dc.contributor.authorGonzález, Narjol
dc.contributor.authorBlonde, Carlos
dc.date.accessioned2022-03-28T19:10:13Z
dc.date.available2022-03-28T19:10:13Z
dc.date.issued2021
dc.description.abstractCampylobacter jejuni and Campylobacter coli are the leading cause of human gastroenteritis in the industrialized world and an emerging threat in developing countries. The incidenceof campylobacteriosis in South America is greatly underestimated, mostly due to the lack of adequate diagnostic methods. Accordingly, there is limited genomic and epidemiological data from this region. In the present study, we performed a genome-wide analysis of the genetic diversity, virulence, and antimicrobial resistance of the largest collection of clinical C. jejuni and C. coli strains from Chile available to date (n = 81), collected in 2017–2019 in Santiago, Chile. This culture collection accounts for more than one third of the available genome sequences from South American clinical strains. cgMLST analysis identified high genetic diversity as well as 13 novel STs and alleles in both C. jejuni and C. coli. Pangenome and virulome analyses showed a differential distribution of virulence factors, including both plasmid and chromosomally encoded T6SSs and T4SSs. Resistome analysis predicted widespread resistance to fluoroquinolones, but low rates of erythromycin resistance. This study provides valuable genomic and epidemiological data and highlights the need for further genomic epidemiology studies in Chile and other South American countries to better understand molecular epidemiology and antimicrobial resistance of this emerging intestinal pathogen.es
dc.description.versionVersión publicadaes
dc.identifier.citationBravo V, Katz A, Porte L, Weitzel T, Varela C, Gonzalez-Escalona N, et al. (2021) Genomic analysis of the diversity, antimicrobial resistance and virulence potential of clinical Campylobacter jejuni and Campylobacter coli strains from Chile. PLoS Negl Trop Dis 15(2): e0009207. https://doi. org/10.1371/journal.pntd.0009207es
dc.identifier.urihttps://doi.org/10.1371/journal.pntd.0009207es
dc.identifier.urihttp://hdl.handle.net/11447/5831
dc.language.isoenes
dc.subjectAnti-Bacterial Agents / pharmacologyes
dc.subjectCampylobacter Infectionses
dc.subjectCampylobacter jejuni / classificationes
dc.subjectMicrobial Sensitivity Testses
dc.subjectAntimicrobial resistancees
dc.subjectVirulence / geneticses
dc.subjectCampylobacter jejuni / geneticses
dc.subjectCampylobacter jejuni / drug effectses
dc.subjectCampylobacter jejuni / classificationes
dc.subjectDrug Resistance, Bacterial / geneticses
dc.subjectGastroenteritises
dc.subjectFluoroquinolones / pharmacologyes
dc.titleGenomic analysis of the diversity, antimicrobial resistance and virulence potential of clinical Campylobacter jejuni and Campylobacter coli strains from Chilees
dc.typeArticlees
dcterms.sourcePLoS neglected tropical diseaseses

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