Identification of clinical phenotypes of peripheral involvement in patients with spondyloarthritis, including psoriatic arthritis: a cluster analysis in the worldwide ASAS-PerSpA study

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dc.contributor.authorLópez, Clementina
dc.contributor.authorChevret, Sylvie
dc.contributor.authorMolto, Anna
dc.contributor.authorSieper, Joachim
dc.contributor.authorDuruöz, Tuncay
dc.contributor.authorKiltz, Uta
dc.contributor.authorElzorkany, Bassel
dc.contributor.authorHajjaj, Najia
dc.contributor.authorBurgos, Ruben
dc.contributor.authorMaldonado, José
dc.contributor.authorZiade, Nelly
dc.contributor.authorGavali, Meghna
dc.contributor.authorNavarro, Victoria
dc.contributor.authorLuo, Shue
dc.contributor.authorBiglia, Alessandro
dc.contributor.authorTae, Kim
dc.contributor.authorKishimoto, Mitsumasa
dc.contributor.authorPimentel, Fernando
dc.contributor.authorGu, Jieruo
dc.contributor.authorVan Gaalen, Floris
dc.contributor.authorMuntean, Laura
dc.contributor.authorGeher, Pál
dc.contributor.authorMagrey, Marina
dc.contributor.authorIbáñez, Sebastián
dc.contributor.authorBautista, Wilson
dc.contributor.authorMaksymowych, Walter
dc.contributor.authorMachado, Pedro
dc.contributor.authorLandewé, Robert
dc.contributor.authorVan der Heijde, Desirée
dc.contributor.authorDougados, Maxime
dc.date.accessioned2022-04-05T19:28:22Z
dc.date.available2022-04-05T19:28:22Z
dc.date.issued2021
dc.description.abstractObjective: To identify clusters of peripheral involvement according to the specific location of peripheral manifestations (ie, arthritis, enthesitis and dactylitis) in patients with spondyloarthritis (SpA) including psoriatic arthritis (PsA), and to evaluate whether these clusters correspond with the clinical diagnosis of a rheumatologist. Methods: Cross-sectional study with 24 participating countries. Consecutive patients diagnosed by their rheumatologist as PsA, axial SpA or peripheral SpA were enrolled. Four different cluster analyses were conducted: one using information on the specific location from all the peripheral manifestations, and a cluster analysis for each peripheral manifestation, separately. Multiple correspondence analyses and k-means clustering methods were used. Distribution of peripheral manifestations and clinical characteristics were compared across the different clusters. Results: The different cluster analyses performed in the 4465 patients clearly distinguished a predominantly axial phenotype (cluster 1) and a predominantly peripheral phenotype (cluster 2). In the predominantly axial phenotype, hip involvement and lower limb large joint arthritis, heel enthesitis and lack of dactylitis were more prevalent. In the predominantly peripheral phenotype, different subgroups were distinguished based on the type and location of peripheral involvement: a predominantly involvement of upper versus lower limbs joints, a predominantly axial enthesitis versus peripheral enthesitis, and predominantly finger versus toe involvement in dactylitis. A poor agreement between the clusters and the rheumatologist's diagnosis as well as with the classification criteria was found. Conclusion: These results suggest the presence of two main phenotypes (predominantly axial and predominantly peripheral) based on the presence and location of the peripheral manifestations.es
dc.description.versionVersión publicada
dc.identifier.citationLópez-Medina C, Chevret S, Molto A, Sieper J, Duruöz T, Kiltz U, Elzorkany B, Hajjaj-Hassouni N, Burgos-Vargas R, Maldonado-Cocco J, Ziade N, Gavali M, Navarro-Compan V, Luo SF, Biglia A, Tae-Jong K, Kishimoto M, Pimentel-Santos FM, Gu J, Muntean L, van Gaalen FA, Geher P, Magrey M, Ibáñez-Vodnizza SE, Bautista-Molano W, Maksymowych W, Machado PM, Landewé R, van der Heijde D, Dougados M. Identification of clinical phenotypes of peripheral involvement in patients with spondyloarthritis, including psoriatic arthritis: a cluster analysis in the worldwide ASAS-PerSpA study. RMD Open. 2021 Nov;7(3):e001728. doi: 10.1136/rmdopen-2021-001728es
dc.identifier.urihttps://doi.org/10.1136/rmdopen-2021-001728es
dc.identifier.urihttp://hdl.handle.net/11447/5935
dc.language.isoenes
dc.subjectAnkylosinges
dc.subjectArthritises
dc.subjectPsoriatices
dc.subjectSpondylitises
dc.titleIdentification of clinical phenotypes of peripheral involvement in patients with spondyloarthritis, including psoriatic arthritis: a cluster analysis in the worldwide ASAS-PerSpA studyes
dc.typeArticlees
dcterms.sourceRMD openes

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