HEM1 deficiency disrupts mTORC2 and F-actin control in inherited immunodysregulatory disease

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dc.contributor.authorCook, Sarah A
dc.contributor.authorComrie, William A
dc.contributor.authorPoli, Cecilia
dc.contributor.authorSimiluk, Morgan
dc.contributor.authorOler, Andrew J
dc.contributor.authorFaruqi, Aiman J
dc.contributor.authorKuhns, Douglas B
dc.contributor.authorYang, Sheng
dc.contributor.authorVargas-Hernández, Alexander
dc.contributor.authorCarisey, Alexandre F
dc.contributor.authorFournier, Benjamin
dc.contributor.authorAnderson, D Eric
dc.contributor.authorPrice, Susan
dc.contributor.authorSmelkinson, Margery
dc.contributor.authorAbou Chahla, Wadih
dc.contributor.authorForbes, Lisa R
dc.contributor.authorMace, Emily M
dc.contributor.authorCao, Tram N
dc.contributor.authorCoban-Akdemir, Zeynep H
dc.contributor.authorJhangiani, Shalini N
dc.date.accessioned2021-10-28T14:49:29Z
dc.date.available2021-10-28T14:49:29Z
dc.date.issued2020
dc.descriptionDonna M Muzny, Richard A Gibbs, James R Lupski , Jordan S Orange, Geoffrey D E Cuvelier , Moza Al Hassani , Nawal Al Kaabi , Zain Al Yafei , Soma Jyonouchi , Nikita Raje , Jason W Caldwell , Yanping Huang , Janis K Burkhardt , Sylvain Latour , Baoyu Chen , Gehad ElGhazali , V Koneti Rao , Ivan K Chinn , Michael J Lenardoes
dc.description.abstractImmunodeficiency often coincides with hyperactive immune disorders such as autoimmunity, lymphoproliferation, or atopy, but this coincidence is rarely understood on a molecular level. We describe five patients from four families with immunodeficiency coupled with atopy, lymphoproliferation, and cytokine overproduction harboring mutations in NCKAP1L, which encodes the hematopoietic-specific HEM1 protein. These mutations cause the loss of the HEM1 protein and the WAVE regulatory complex (WRC) or disrupt binding to the WRC regulator, Arf1, thereby impairing actin polymerization, synapse formation, and immune cell migration. Diminished cortical actin networks caused by WRC loss led to uncontrolled cytokine release and immune hyperresponsiveness. HEM1 loss also blocked mechanistic target of rapamycin complex 2 (mTORC2)-dependent AKT phosphorylation, T cell proliferation, and selected effector functions, leading to immunodeficiency. Thus, the evolutionarily conserved HEM1 protein simultaneously regulates filamentous actin (F-actin) and mTORC2 signaling to achieve equipoise in immune responseses
dc.identifier.citationScience 2020 Jul 10;369(6500):202-207es
dc.identifier.urihttp://hdl.handle.net/11447/4963
dc.language.isoen_USes
dc.titleHEM1 deficiency disrupts mTORC2 and F-actin control in inherited immunodysregulatory diseasees
dc.typeArticlees

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