Redox-mediated regulation of connexin proteins; focus on nitric oxide
Date
2017
Type:
Artículo
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5
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Journal Title
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Volume Title
Publisher
Elsevier
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Abstract
Connexins are membrane proteins that form hemichannels and gap junction channels at the plasma
membrane. Through these channels connexins participate in autocrine and paracrine intercellular
communication. Connexin-based channels are tightly regulated by membrane potential,
phosphorylation, pH, redox potential, and divalent cations, among others, and the imbalance of this
regulation have been linked to many acquired and genetic diseases. Concerning the redox potential
regulation, the nitric oxide (NO) has been described as a modulator of the hemichannels and gap
junction channels properties. However, how NO regulates these channels is not well understood. In
this mini-review, we summarize the current knowledge about the effects of redox potential focused
in NO on the trafficking, formation and functional properties of hemichannels and gap junction
channels.
Description
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Citation
Biochim Biophys Acta. 2018 Jan;1860(1):91-95
Keywords
Gap junction channel, Hemichannel, Redox potential, Nitric oxide