Polygenic score analysis identifies distinct genetic risk profiles in Alzheimer’s disease comorbidities

Hernández, Carlos F.; Villaman, Camilo; Leu, Costin; Lal, Dennis; Mata, Ignacio; Klein, Andrés; Pérez-Palma, Eduardo

Publication:
Polygenic score analysis identifies distinct genetic risk profiles in Alzheimer’s disease comorbidities

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s41598-025-95755-8.pdf (1.77 MB)

Date

2025

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Article

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Artículos Medicina y Ciencias de la Salud

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https://doi.org/10.1038/s41598-025-95755-8

URI

https://hdl.handle.net/11447/11042

item.page.extent

9 p.

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Acceso abierto

Abstract

Alzheimer’s disease (AD) is usually accompanied by comorbidities such as type 2 diabetes (T2D), epilepsy, major depressive disorder (MDD), and migraine headaches (MH) that can significantly affect pat...

Citation

Hernández, C.F., Villaman, C., Leu, C. et al. Polygenic score analysis identifies distinct genetic risk profiles in Alzheimer’s disease comorbidities. Sci Rep 15, 11407 (2025). https://doi.org/10.1038/s41598-025-95755-8

Keywords

PGS , Comorbidities , Common variants , PRS

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Atribución-NoComercial-CompartirIgual 3.0 Chile (CC BY-NC-SA 3.0 CL)

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http://creativecommons.org/licenses/by-nc-sa/3.0/cl/

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