A prospective cohort multicenter study of molecular epidemiology and phylogenomics of Staphylococcus aureus bacteremia in nine Latin American countries
dc.contributor.author | Arias, Cesar A | |
dc.contributor.author | Reyes, Jinnethe | |
dc.contributor.author | Carvajal, Lina | |
dc.contributor.author | Rincon, Sandra | |
dc.contributor.author | Diaz, Lorena | |
dc.contributor.author | Panesso, Diana | |
dc.contributor.author | Ibarra, Gabriel | |
dc.contributor.author | Rios, Rafael | |
dc.contributor.author | Munita, José | |
dc.contributor.author | Salles, Mauro J | |
dc.contributor.author | Alvarez-Moreno, Carlos | |
dc.contributor.author | Labarca, Jaime | |
dc.contributor.author | Garcia, Coralith | |
dc.contributor.author | Luna, Carlos M | |
dc.contributor.author | Mejia-Villatoro, Carlos | |
dc.contributor.author | Zurita, Jeanette | |
dc.contributor.author | Guzman-Blanco, Manuel | |
dc.contributor.author | Rodriguez-Noriega, Eduardo | |
dc.contributor.author | Narechania, Apurva | |
dc.contributor.author | Rojas, Laura J | |
dc.contributor.author | Planet, Paul J | |
dc.contributor.author | Weinstock, George M | |
dc.contributor.author | Gotuzzo, Eduardo | |
dc.contributor.author | Seasg, Carlos | |
dc.date.accessioned | 2022-01-10T14:35:03Z | |
dc.date.available | 2022-01-10T14:35:03Z | |
dc.date.issued | 2017 | |
dc.description.abstract | Staphylococcus aureus is an important pathogen causing a spectrum of diseases ranging from mild skin and soft tissue infections to life-threatening conditions. Bloodstream infections are particularly important, and the treatment approach is complicated by the presence of methicillin-resistant S. aureus (MRSA) isolates. The emergence of new genetic lineages of MRSA has occurred in Latin America (LA) with the rise and dissemination of the community-associated USA300 Latin American variant (USA300-LV). Here, we prospectively characterized bloodstream MRSA recovered from selected hospitals in 9 Latin American countries. All isolates were typed by pulsed-field gel electrophoresis (PFGE) and subjected to antibiotic susceptibility testing. Whole-genome sequencing was performed on 96 MRSA representatives. MRSA represented 45% of all (1,185 S. aureus) isolates. The majority of MRSA isolates belonged to clonal cluster (CC) 5. In Colombia and Ecuador, most isolates (72%) belonged to the USA300-LV lineage (CC8). Phylogenetic reconstructions indicated that MRSA isolates from participating hospitals belonged to three major clades. Clade A grouped isolates with sequence type 5 (ST5), ST105, and ST1011 (mostly staphylococcal chromosomal cassette mec [SCCmec] I and II). Clade B included ST8, ST88, ST97, and ST72 strains (SCCmec IV, subtypes a, b, and c/E), and clade C grouped mostly Argentinian MRSA belonging to ST30. In summary, CC5 MRSA was prevalent in bloodstream infections in LA with the exception of Colombia and Ecuador, where USA300-LV is now the dominant lineage. Clonal replacement appears to be a common phenomenon, and continuous surveillance is crucial to identify changes in the molecular epidemiology of MRSA. | es |
dc.identifier.citation | Arias CA, Reyes J, Carvajal LP, Rincon S, Diaz L, Panesso D, Ibarra G, Rios R, Munita JM, Salles MJ, Alvarez-Moreno C, Labarca J, Garcia C, Luna CM, Mejia-Villatoro C, Zurita J, Guzman-Blanco M, Rodriguez-Noriega E, Narechania A, Rojas LJ, Planet PJ, Weinstock GM, Gotuzzo E, Seas C. A Prospective Cohort Multicenter Study of Molecular Epidemiology and Phylogenomics of Staphylococcus aureus Bacteremia in Nine Latin American Countries. Antimicrob Agents Chemother. 2017 Sep 22;61(10):e00816-17. | es |
dc.identifier.uri | http://dx.doi.org/10.1128/AAC.00816-17 | es |
dc.identifier.uri | http://hdl.handle.net/11447/5378 | |
dc.language.iso | en_US | es |
dc.subject | Bacteremia | es |
dc.subject | Latin America | es |
dc.subject | Staphylococcus aureus | es |
dc.title | A prospective cohort multicenter study of molecular epidemiology and phylogenomics of Staphylococcus aureus bacteremia in nine Latin American countries | es |
dc.type | Article | es |
Files
Original bundle
1 - 1 of 1
Loading...
- Name:
- A Prospective Cohort Multicenter Study of Molecular Epidemiology and Phylogenonnics of Staphylococcus aureus Bacterennia in Nine Latin American Countries.pdf
- Size:
- 1.94 MB
- Format:
- Adobe Portable Document Format
- Description:
- Texto completo
License bundle
1 - 1 of 1
No Thumbnail Available
- Name:
- license.txt
- Size:
- 1.71 KB
- Format:
- Item-specific license agreed upon to submission
- Description: