Diseases associated with leaky hemichannels

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dc.contributor.authorRetamal, Mauricio
dc.contributor.authorReyes, Edison
dc.contributor.authorGarcia, Isaac
dc.contributor.authorPinto, Bernardo
dc.contributor.authorMartinez, Agustin
dc.contributor.authorGonzalez, Carlos
dc.date.accessioned2017-05-19T04:31:14Z
dc.date.available2017-05-19T04:31:14Z
dc.date.issued2015
dc.descriptionCentro de Fisiología Celular e Integrativa
dc.description.abstractHemichannels (HCs) and gap junction channels (GJCs) formed by protein subunits called connexins (Cxs) are major pathways for intercellular communication. While HCs connect the intracellular compartment with the extracellular milieu, GJCs allow the interchange of molecules between cytoplasm of two contacting cells. Under physiological conditions, HCs are mostly closed, but they can open under certain stimuli allowing the release of autocrine and paracrine molecules. Moreover, some pathological conditions, like ischemia or other inflammation conditions, significantly increase HCs activity. In addition, some mutations in Cx genes associated with human diseases, such as deafness or cataracts, lead to the formation of more active HCs or "leaky HCs." In this article we will revise cellular and molecular mechanisms underlying the appearance of leaky HCs, and the consequences of their expression in different cellular systems and animal models, in seeking a common pattern or pathological mechanism of disease.
dc.format.extent10
dc.identifier.citationFront Cell Neurosci. 2015 Jul 27;9:267
dc.identifier.urihttp://hdl.handle.net/11447/1176
dc.identifier.urihttp://dx.doi.org/10.3389/fncel.2015.00267
dc.language.isoen_US
dc.publisherFrontiers Research Foundation
dc.subjectcell death
dc.subjectconnexins
dc.subjectdisease
dc.subjectgap junction channels
dc.subjectleaky hemichannels
dc.subjectmutations
dc.titleDiseases associated with leaky hemichannels
dc.typeArtículo

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