Replenishment of type VII collagen and re-epithelialization of chronically ulcerated skin after intradermal administration of allogeneic mesenchymal stromal cells in two patients with recessive dystrophic epidermolysis bullosa

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dc.contributor.authorCONGET, PAULETTE
dc.contributor.authorRODRIGUEZ, FERNANDO
dc.contributor.authorKRAMER, SUSANNE
dc.contributor.authorALLERS, CAROLINA
dc.contributor.authorSIMON, VALESKA
dc.contributor.authorPalisson, Francis
dc.contributor.authorGONZALEZ, SERGIO
dc.contributor.authorYUBERO, MARIA J.
dc.date.accessioned2021-10-25T15:06:34Z
dc.date.available2021-10-25T15:06:34Z
dc.date.issued2010
dc.description.abstractIn animal models it has been shown that mesenchymal stromal cells (MSC) contribute to skin regeneration and accelerate wound healing. We evaluated whether allogeneic MSC administration resulted in an improvement in the skin of two patients with recessive dystrophic epidermolysis bullosa (RDEB; OMIM 226600). Patients had absent type VII collagen immunohistofl uorescence and since birth had suffered severe blistering and wounds that heal with scarring. Vehicle or 0.5 106 MSC were infused intradermally in intact and chronic ulcerated sites. One week after intervention, in MSC-treated skin type VII collagen was detected along the basement membrane zone and the dermal–epidermal junction was continuous. Re-epithelialization of chronic ulcerated skin was observed only near MSC administration sites. In both patients the observed clinical benefi t lasted for 4 months. Thus intradermal administration of allogeneic MSC associates with type VII collagen replenishment at the dermal–epidermal junction, prevents blistering and improves wound healing in unconditioned patients with RDEB.es
dc.identifier.citationCytotherapy, 2010; 12: 429–431es
dc.identifier.urihttps://doi.org/10.3109/14653241003587637es
dc.identifier.urihttp://hdl.handle.net/11447/4897
dc.language.isoen_USes
dc.subjectchronic wound healinges
dc.subjectdystrophic epidermolysis bullosaes
dc.subjectmesenchymal stromal celles
dc.titleReplenishment of type VII collagen and re-epithelialization of chronically ulcerated skin after intradermal administration of allogeneic mesenchymal stromal cells in two patients with recessive dystrophic epidermolysis bullosaes
dc.typeArticlees

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