Modulation of gap junction channels and hemichannels by growth factors

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dc.contributor.authorSchalper, Kurt A.
dc.contributor.authorRiquelme, Manuel A.
dc.contributor.authorMartínez, Agustín D.
dc.contributor.authorVega, José Luis
dc.contributor.authorBerthoud, Viviana M.
dc.contributor.authorBennett, Michael V. L.
dc.contributor.authorSáez, Juan C.
dc.contributor.authorBrañez, María C.
dc.date.accessioned2021-10-04T14:16:57Z
dc.date.available2021-10-04T14:16:57Z
dc.date.issued2012
dc.description.abstractGap junction hemichannels and cell–cell channels have roles in coordinating numerous cellular processes, due to their permeability to extra and intracellular signaling molecules. Another mechanism of cellular coordination is provided by a vast array of growth factors that interact with relatively selective cell membrane receptors. These receptors can affect cellular transduction pathways, including alteration of intracellular concentration of free Ca2+ and free radicals and activation of protein kinases or phosphatases. Connexin and pannexin based channels constitute recently described targets of growth factor signal transduction pathways, but little is known regarding the effects of growth factor signaling on pannexin based channels. The effects of growth factors on these two channel types seem to depend on the cell type, cell stage and connexin and pannexin isoform expressed. The functional state of hemichannels and gap junction channels are affected in opposite directions by FGF-1 via protein kinase-dependent mechanisms. These changes are largely explained by channels insertion in or withdrawal from the cell membrane, but changes in open probability might also occur due to changes in phosphorylation and redox state of channel subunits. The functional consequence of variation in cell–cell communication via these membrane channels is implicated in disease as well as normal cellular responses.es
dc.identifier.citationMolecular BioSystems, 2012, 8: 685–698es
dc.identifier.urihttp://dx.doi.org/10.1039/c1mb05294bes
dc.identifier.urihttp://hdl.handle.net/11447/4773
dc.language.isoenes
dc.subjectAnimalses
dc.subjectCell Communicationes
dc.subjectConnexins / metabolismes
dc.subjectFibroblast Growth Factor 1 / metabolismes
dc.subjectGap Junctions / metabolismes
dc.subjectHumanses
dc.subjectIntercellular Signaling Peptides and Proteins / metabolismes
dc.subjectIon Channels / metabolismes
dc.subjectSignal Transductiones
dc.titleModulation of gap junction channels and hemichannels by growth factorses
dc.typeArticlees

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