Plasticity of cardiovascular chemoreflexes after prolonged unilateral carotid body denervation: implications for its therapeutic use

Simple item page
dc.contributor.authorEugenín, Jaime
dc.contributor.authorLarraín, Carolina
dc.contributor.authorZapata, Patricio
dc.date.accessioned2021-08-17T17:23:31Z
dc.date.available2021-08-17T17:23:31Z
dc.date.issued2020
dc.description.abstractUnilateral carotid body denervation has been proposed as treatment for sympathetic-related human diseases such as systolic heart failure, hypertension, obstructive sleep apnea, and cardiometabolic diseases. The long-term therapeutic effects of carotid body removal will be maintained if the remnant “buffer nerves,” that is, the contralateral carotid nerve and the aortic nerves that innervate second-order neurons at the solitary tract nuclei (NTS), do not modify their contributions to the cardiovascular chemoreflexes. Here, we studied the cardiovascular chemoreflexes 1 mo after unilateral carotid body denervation either by excision of the petrosal ganglion (petrosal ganglionectomy, which eliminates central carotid afferents) or exeresis of a segment of one carotid nerve (carotid neurectomy, which preserves central afferents). Cardiovascular chemoreflexes were induced by intravenous (iv) injections of sodium cyanide in pentobarbitone-anesthetized adult cats. After 1 mo of unilateral petrosal ganglionectomy, without significant changes in basal arterial pressure, the contribution of the contralateral carotid nerve to the chemoreflex increases in arterial pressure was enhanced without changes in the contribution provided by the aortic nerves. By contrast, after 1 mo of unilateral carotid neurectomy, the contribution of remnant buffer nerves to cardiovascular chemoreflexes remained unmodified. These results indicate that a carotid nerve interruption involving denervation of second-order chemosensory neurons at the NTS will trigger cardiovascular chemoreflex plasticity on the contralateral carotid pathway. Then, unilateral carotid body denervation as therapeutic tool should consider the maintenance of the integrity of carotid central chemoafferents to prevent plasticity on remnant buffer nerves. NEW & NOTEWORTHY Unilateral carotid body denervation has been proposed as treatment for sympathetic hyperactivity-related human disorders. Its therapeutic effectiveness for maintaining a persistent decrease in the sympathetic outflow activity will depend on the absence of compensatory chemoreflex plasticity in the remnant carotid and aortic afferents. Here, we suggest that the integrity of central afferents after carotid body denervation is essential to prevent the emergence of plastic functional changes on the contralateral “intact” carotid nerve.es
dc.identifier.citationAmerican Journal of Physiology-Heart and Circulatory Physiology, 2020, vol.318: H1325–H1336es
dc.identifier.urihttps://dx.doi.org/10.1152/ajpheart.00451.2019es
dc.identifier.urihttp://hdl.handle.net/11447/4344
dc.language.isoenes
dc.subjectCardiovascular chemoreflexeses
dc.subjectArterial pressure controles
dc.subjectCarotid body denervationes
dc.subjectHeart rate controles
dc.subjectPetrosal ganglionectomyes
dc.titlePlasticity of cardiovascular chemoreflexes after prolonged unilateral carotid body denervation: implications for its therapeutic usees
dc.typeArticlees

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Plasticity of cardiovascular chemoreflexes after prolonged unilateral carotid body denervation implications for its therapeutics use.pdf
Size:
1.12 MB
Format:
Adobe Portable Document Format
Description:
Texto completo
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Artículos Medicina y Ciencias de la Salud

Implementado por OpenGeek Services