Role of proteases in dysfunctional placental vascular remodelling in preeclampsia

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dc.contributor.authorGutiérrez, Jaime
dc.contributor.authorGómez, Isabel
dc.contributor.authorChiarello, Delia
dc.contributor.authorSalsoso, Rocío
dc.contributor.authorKlein, Andrés
dc.contributor.authorGuzmán-Gutiérrez, Enrique
dc.contributor.authorToledo, Fernando
dc.contributor.authorSobrevia, Luis
dc.date.accessioned2020-01-23T19:00:11Z
dc.date.available2020-01-23T19:00:11Z
dc.date.issued2019
dc.descriptionCentro de Genética y Genómica (ICIM)
dc.description.abstractPreeclampsia is a syndrome characterised by vascular dysfunction, impaired angiogenesis, and hypertension during pregnancy. Even when the precise pathophysiology of preeclampsia remains elusive, impaired vascular remodelling and placental angiogenesis in the placental villi and defective trophoblast invasion of the uterus are proposed as crucial mechanisms in this syndrome. Reduced trophoblast invasion leads to reduced uteroplacental blood flow and oxygen availability and increased oxidative stress. These phenomena trigger the release of soluble factors into the maternal and foetoplacental circulation that are responsible of the clinical features of preeclampsia. New blood vessels generation as well as vascular remodelling are mechanisms that require expression and activity of different proteases, including matrix metalloproteases, a-disintegrin and metalloproteases, and a-disintegrin and metalloprotease with thrombospondin motifs. These proteases exert proteolysis of the extracellular matrix. Additionally, cathepsins, a family of proteolytic enzymes, are primarily located in lysosomes but are also released by cells to the extracellular space. This review focuses on the role that these proteases play in the regulation of the uterine trophoblast invasion and the placental vascular remodellingassociated with preeclampsia.
dc.identifier.citationJ.A. Gutiérrez, I. Gómez, D.I. Chiarello, et al., Role of proteases in dysfunctional placental vascular remodelling in preeclampsia, BBA - Molecular Basis of Disease, https://doi.org/10.1016/j.bbadis.2019.04.004
dc.identifier.urihttp://hdl.handle.net/11447/3065
dc.identifier.urihttps://doi.org/10.1016/j.bbadis.2019.04.004
dc.language.isoen
dc.publisherElsevier B.V.
dc.subjectProteases
dc.subjectAngiogenesis
dc.subjectVascular remodelling
dc.subjectPlacenta
dc.subjectPreeclampsia
dc.titleRole of proteases in dysfunctional placental vascular remodelling in preeclampsia

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