Petrosal ganglion: a more complex role than originally imagined

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dc.contributor.authorRetamal, Mauricio
dc.contributor.authorReyes, Edison
dc.contributor.authorAlcayaga, Julio
dc.date.accessioned2017-03-06T22:50:20Z
dc.date.available2017-03-06T22:50:20Z
dc.date.issued2014
dc.descriptionCentro de Fisiología Celular e Integrativa
dc.description.abstractThe petrosal ganglion (PG) is a peripheral sensory ganglion, composed of pseudomonopolar sensory neurons that innervate the posterior third of the tongue and the carotid sinus and body. According to their electrical properties PG neurons can be ascribed to one of two categories: (i) neurons with action potentials presenting an inflection (hump) on its repolarizing phase and (ii) neurons with fast and brisk action potentials. Although there is some correlation between the electrophysiological properties and the sensory modality of the neurons in some species, no general pattern can be easily recognized. On the other hand, petrosal neurons projecting to the carotid body are activated by several transmitters, with acetylcholine and ATP being the most conspicuous in most species. Petrosal neurons are completely surrounded by a multi-cellular sheet of glial (satellite) cells that prevents the formation of chemical or electrical synapses between neurons. Thus, PG neurons are regarded as mere wires that communicate the periphery (i.e., carotid body) and the central nervous system. However, it has been shown that in other sensory ganglia satellite glial cells and their neighboring neurons can interact, partly by the release of chemical neuro-glio transmitters. This intercellular communication can potentially modulate the excitatory status of sensory neurons and thus the afferent discharge. In this mini review, we will briefly summarize the general properties of PG neurons and the current knowledge about the glial-neuron communication in sensory neurons and how this phenomenon could be important in the chemical sensory processing generated in the carotid body.
dc.format.extent7
dc.identifier.citationFront Physiol. 2014; 5: 474.
dc.identifier.urihttp://hdl.handle.net/11447/1004
dc.identifier.urihttp://dx.doi.org/10.3389/fphys.2014.00474
dc.language.isoen_US
dc.publisherFrontiers Research Foundation
dc.subjectpetrosal ganglia
dc.subjectsensory modality
dc.subjectchemosensory
dc.subjectmechanosensory
dc.subjectaction potential
dc.titlePetrosal ganglion: a more complex role than originally imagined
dc.typeArtículo

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