Intravenous administration of anti-inflammatory mesenchymal stem cell spheroids reduces chronic alcohol intake and abolishes bingedrinking

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dc.contributor.authorEzquer, Fernando
dc.contributor.authorMorales, Paola
dc.contributor.authorQuintanilla, María Elena
dc.contributor.authorSantapau, Daniela
dc.contributor.authorLespay-Rebolledo, Carolyne
dc.contributor.authorEzquer, Marcelo
dc.contributor.authorHerrera-Marschitz, Marcelo
dc.contributor.authorIsrael, Yedy
dc.date.accessioned2021-09-02T20:47:13Z
dc.date.available2021-09-02T20:47:13Z
dc.date.issued2018
dc.description.abstractChronic alcohol intake leads to neuroinflammation and astrocyte dysfunction, proposed to perpetuate alcohol consumption and to promote conditioned relapse-like binge drinking. In the present study, human mesenchymal stem cells (MSCs) were cultured in 3D-conditions to generate MSC-spheroids, which greatly increased MSCs anti-inflammatory ability and reduced cell volume by 90% versus conventionally 2D-cultured MSCs, enabling their intravenous administration and access to the brain. It is shown, in an animal model of chronic ethanol intake and relapse-drinking, that both the intravenous and intra-cerebroventricular administration of a single dose of MSC-spheroids inhibited chronic ethanol intake and relapse-like drinking by 80–90%, displaying significant effects over 3–5 weeks. The MSC-spheroid administration fully normalized alcohol-induced neuroinflammation, as shown by a reduced astrocyte activation, and markedly increased the levels of the astrocyte Na-glutamate (GLT-1) transporter. This research suggests that the intravenous administration of MSC-spheroids may constitute an effective new approach for the treatment of alcohol-use disorders.es
dc.identifier.urihttps://doi.org/10.1038/s41598-018-22750-7es
dc.identifier.urihttp://hdl.handle.net/11447/4574
dc.language.isoenes
dc.publisherScientific Reports; 2018; 8:4325es
dc.titleIntravenous administration of anti-inflammatory mesenchymal stem cell spheroids reduces chronic alcohol intake and abolishes bingedrinkinges
dc.typeArticlees

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