Results of Liver Transplantation for Hepatocellular Carcinoma in a Multicenter Latin American Cohort Study

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dc.contributor.authorPiñero, Federico
dc.contributor.authorCosta, Paulo
dc.contributor.authorBoteon, Yuri L.
dc.contributor.authorHoyos Duque, Sergio
dc.contributor.authorMarciano, Sebastián
dc.contributor.authorAnders, Margarita
dc.contributor.authorVarón, Adriana
dc.contributor.authorZerega, Alina
dc.contributor.authorPoniachik, Jaime
dc.contributor.authorSoza, Alejandro
dc.contributor.authorPadilla Machaca, Martín
dc.contributor.authorMenéndez, Josemaría
dc.contributor.authorZapata, Rodrigo
dc.contributor.authorVilatoba, Mario
dc.contributor.authorMuñoz, Linda
dc.contributor.authorMaraschio, Martín
dc.contributor.authorFauda, Martín
dc.contributor.authorMcCormack, Lucas
dc.contributor.authorGadano, Adrián
dc.contributor.authorBoin, Ilka S.F.
dc.contributor.authorParente García, José H.
dc.contributor.authorSilva, Marcelo
dc.date.accessioned2022-06-03T16:04:13Z
dc.date.available2022-06-03T16:04:13Z
dc.date.issued2018
dc.description.abstractBackground and aims. Heterogeneous data has been reported regarding liver transplantation (LT) for hepatocellular carcinoma (HCC) in Latin America. We aimed to describe treatment during waiting list, survival and recurrence of HCC after LT in a multicenter study from Latin America. Material and methods. Patients with HCC diagnosed prior to transplant (cHCC) and incidentally found in the explanted liver (iHCC) were included. Imaging-explanted features were compared in cHCC (non-discordant if pre and post-LT were within Milan, discordant if pre-LT was within and post-LT exceeding Milan). Results. Overall, 435 patients with cHCC and 92 with iHCC were included. At listing, 81% and 91% of cHCC patients were within Milan and San Francisco criteria (UCSF), respectively. Five-year survival and recurrence rates for cHCC within Milan, exceeding Milan/within UCSF and beyond UCSF were 71% and 16%; 66% and 26%; 46% and 55%, respectively. Locoregional treatment prior to LT was performed in 39% of cHCC within Milan, in 53% beyond Milan/within UCSF and in 83% exceeding UCSF (p < 0.0001). This treatment difference was not observed according to AFP values (d100, 44%; 101-1,000, 39%, and > 1,000 ng/mL 64%; p = 0.12). Discordant imaging-explanted data was observed in 29% of cHCC, showing lower survival HR 2.02 (CI 1.29; 3.15) and higher recurrence rates HR 2.34 when compared to AFP <100 ng/mL. Serum AFP > 1,000 ng/mL at listing was independently associated with a higher 5-year recurrence rate and a HR of 3.24 when compared to AFP <100 ng/mL. Conclusion. Although overall results are comparable to other regions worldwide, pre-LT treatment not only considering imaging data but also AFP values should be contemplated during the next yearses
dc.description.versionVersión Publicadaes
dc.identifier.citationPiñero F, Costa P, Boteon YL, Duque SH, Marciano S, Anders M, Varón A, Zerega A, Poniachik J, Soza A, Machaca MP, Menéndez J, Zapata R, Vilatoba M, Muñoz L, Maraschio M, Fauda M, McCormack L, Gadano A, Boin IS, García JHP, Silva M. Results of Liver Transplantation for Hepatocellular Carcinoma in a Multicenter Latin American Cohort Study. Ann Hepatol. 2018 Mar 1;17(2):256-267. doi: 10.5604/01.3001.0010.8648.es
dc.identifier.urihttps://doi.org/10.5604/01.3001.0010.8648es
dc.identifier.urihttp://hdl.handle.net/11447/6183
dc.language.isoenes
dc.subjectLiver canceres
dc.subjectPredictiones
dc.subjectCandidate selectiones
dc.titleResults of Liver Transplantation for Hepatocellular Carcinoma in a Multicenter Latin American Cohort Studyes
dc.typeArticlees
dcterms.sourceAnnals of Hepatologyes

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