Diagnosis of obstructive sleep Apnea in Parkinson's disease patients: Is unattended portable monitoring a suitable tool?

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dc.contributor.authorGros, Priti
dc.contributor.authorMery, Victoria
dc.contributor.authorLafontaine, Anne-Louise
dc.contributor.authorRobinson, Ann
dc.contributor.authorBenedetti, Andrea
dc.contributor.authorKimoff, John
dc.contributor.authorKaminska, Marta
dc.date.accessioned2016-05-23T19:48:32Z
dc.date.available2016-05-23T19:48:32Z
dc.date.issued2015
dc.description.abstractPurpose. Obstructive sleep apnea (OSA) is frequent in Parkinson's disease (PD) and may contribute to nonmotor symptoms. Polysomnography (PSG) is the gold standard for OSA diagnosis. Unattended portable monitoring (PM) may improve access to diagnosis but has not been studied in PD. We assessed feasibility and diagnostic accuracy in PD. Methods. Selected PD patients without known OSA underwent home PM and laboratory PSG. The quality of PM signals (n = 28) was compared with matched controls. PM accuracy was calculated compared with PSG for standard apnea hypopnea index (AHI) thresholds. Results. Technical failure rate was 27.0% and airflow signal quality was lower than in controls. Sensitivity of PM was 84.0%, 36.4%, and 50.0% for AHI cut-offs of 5/h, 15/h, and 30/h, respectively, using the same cut-offs on PM. Specificity was 66.7%, 83.3%, and 100%, respectively. PM underestimated the AHI with a mean bias of 12.4/h. Discrepancy between PM and PSG was greater in those with more motor dysfunction. Conclusion. PM was adequate to "rule in" moderate or severe OSA in PD patients, but the failure rate was relatively high and signal quality poorer than in controls. PM overall underestimated the severity of OSA in PD patients, especially those with greater motor dysfunction.
dc.identifier.citationParkinson’s Disease, 2015, vol. 2015, article ID 258418
dc.identifier.urihttp://hdl.handle.net/11447/321
dc.identifier.urihttp://dx.doi.org/10.1155/2015/258418
dc.language.isoen_US
dc.publisherPriti Gros et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.subjectParkinson
dc.subjectObstructive sleep apnea
dc.subjectDiagnosis
dc.subjectUnattended portable monitoring
dc.titleDiagnosis of obstructive sleep Apnea in Parkinson's disease patients: Is unattended portable monitoring a suitable tool?
dc.typeArtículo

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