Esophagogastric junction morphology and contractile integral on high-resolution manometry in asymptomatic healthy volunteers: An international multicenter study

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dc.contributor.authorRogers, Benjamin D.
dc.contributor.authorRengarajan, Arvind
dc.contributor.authorAbrahao, Luiz
dc.contributor.authorBhatia, Shobna
dc.contributor.authorBor, Serhat
dc.contributor.authorCarlson, Dustin A.
dc.contributor.authorCisternas, Daniel
dc.contributor.authorGonlachanvit, Sutep
dc.date.accessioned2022-05-03T15:43:06Z
dc.date.available2022-05-03T15:43:06Z
dc.date.issued2021
dc.description.abstractBackground: Esophagogastric junction contractile integral (EGJ-CI) and EGJ mor -phology are high-resolution manometry (HRM) metrics that assess EGJ barrier func -tion. Normative data standardized across world regions and HRM manufacturers are limited.Methods: Our aim was to determine normative EGJ metrics in a large international cohort of healthy volunteers undergoing HRM (Medtronic, Laborie, and Diversatek software) acquired from 16 countries in four world regions. EGJ-CI was calculated by the same two investigators using a distal contractile integral-like measurement across the EGJ for three respiratory cycles and corrected for respiration (mm Hg cm), using manufacturer-specific software tools. EGJ morphology was designated according to Chicago Classification v3.0. Median EGJ-CI values were calculated across age, gen -ders, HRM systems, and regions.Results: Of 484 studies (28.0 years, 56.2% F, 60.7% Medtronic studies, 26.0% Laborie, and 13.2% Diversatek), EGJ morphology was type 1 in 97.1%. MedianEGJ-CI was similar between Medtronic (37.0 mm Hg cm, IQR 23.6-53.7 mm Hg cm) and Diversatek (34.9 mm Hg cm, IQR 22.1-56.1 mm Hg cm, P = 0.87), but was signif-icantly higher using Laborie equipment (56.5 mm Hg cm, IQR 35.0-75.3 mm Hg cm, P < 0.001). 5th percentile EGJ-CI values ranged from 6.9 to 12.1 mm Hg cm. EGJ-CI values were consistent across world regions, but different between manufacturers even within the same world region (P ≤ 0.001). Within Medtronic studies, EGJ-CIand basal LESP were similar in younger and older individuals (P ≥ 0.3) but higher in women (P < 0.001).Conclusions: EGJ morphology is predominantly type 1 in healthy adults. EGJ-CI varies widely in health, with significant gender influence, but is consistent within each HRM system. Manufacturer-specific normative values should be utilized for clinical HRM interpretation.es
dc.description.versionVersión Publicadaes
dc.identifier.citationRogers BD, Rengarajan A, Abrahao L, Bhatia S, Bor S, Carlson DA, Cisternas D, Gonlachanvit S, Hani A, Hayat J, Kawamura O, Lee YY, Leguizamo AM, Pauwels A, Perez de la Serna J, Ramos RI, Remes-Troche JM, Roman S, Savarino E, Serra J, Sifrim D, Tolone S, Wong Z, Zerbib F, Pandolfino J, Gyawali CP. Esophagogastric junction morphology and contractile integral on high-resolution manometry in asymptomatic healthy volunteers: An international multicenter study. Neurogastroenterol Motil. 2021 Jun;33(6):e14009. doi: 10.1111/nmo.14009. Epub 2020 Oct 23. PMID: 33094875.es
dc.identifier.urihttps://doi.org/10.1111/nmo.14009es
dc.identifier.urihttp://hdl.handle.net/11447/6049
dc.language.isoenes
dc.subjectBarrier functiones
dc.subjectEsophagogastric junctiones
dc.subjectLower esophageal sphincter pressurees
dc.titleEsophagogastric junction morphology and contractile integral on high-resolution manometry in asymptomatic healthy volunteers: An international multicenter studyes
dc.typeArticlees
dcterms.sourceNeurogastroenterology & Motilityes

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