Rapid Hemostasis in a Sheep Model Using Particles That Propel Thrombin and Tranexamic Acid

Simple item page
dc.contributor.authorBaylis, James R.
dc.contributor.authorFinkelstein-Kulka, Andrés
dc.contributor.authorMacias-Valle, Luis
dc.contributor.authorManji, Jamil
dc.contributor.authorLee, Michael
dc.contributor.authorLevchenko, Elina
dc.contributor.authorOkpaleke, Christopher
dc.contributor.authorAl-Salihi, Salahuddin
dc.contributor.authorJaver, Amin
dc.contributor.authorKastrup, Christian J.
dc.date.accessioned2022-03-07T13:46:05Z
dc.date.available2022-03-07T13:46:05Z
dc.date.issued2017
dc.description.abstractObjectives/Hypothesis: Bleeding during endoscopic sinus surgery and open surgeries can easily obstruct the surgeons’ field of view and increase morbidity and risk of intraoperative complications. Intraoperative bleeding could potentially be addressed by a hemostatic agent that safely disperses itself through the escaping blood. We tested the safety and efficacy of a self-propelling formulation of thrombin and tranexamic acid (SPTT) in stopping bleeding in a paranasal sinus injury and in an open surgical carotid injury sheep model. Study Design: Interventional animal study. Methods: SPTT was tested in the sinonasal space following endoscopic injury to the inferior turbinate of six sheep, and to the common carotid artery following open surgical injury in eight sheep. In the nasal cavity, bleeding time and local inflammation were measured and compared to plain gauze. Following carotid arteriotomy, successful hemostasis and markers of thrombosis and coagulopathy were compared to Floseal. Results: SPTT significantly decreased bleeding times in the sinonasal space compared to plain gauze (mean difference 5 3.8 minutes, P 5 .002). All of the carotid bleeds (100%) were successfully controlled with SPTT after 10 minutes of application under pressure, compared to 25% with Floseal. No adverse events were noted, and there was no evidence of thromboembolism. Conclusions: SPTT significantly reduced bleeding time in a sheep model of surgical sinus bleeding and successfully stopped bleeding following catastrophic carotid artery injury, with no adverse events observed.es
dc.description.versionVersión Publicadaes
dc.identifier.citationR Baylis J, Finkelstein-Kulka A, Macias-Valle L, Manji J, Lee M, Levchenko E, Okpaleke C, Al-Salihi S, Javer A, J Kastrup C. Rapid hemostasis in a sheep model using particles that propel thrombin and tranexamic acid. Laryngoscope. 2017 Apr;127(4):787-793. doi: 10.1002/lary.26408es
dc.identifier.urihttps://doi.org/10.1002/lary.26408es
dc.identifier.urihttp://hdl.handle.net/11447/5668
dc.language.isoenes
dc.titleRapid Hemostasis in a Sheep Model Using Particles That Propel Thrombin and Tranexamic Acides
dc.typeArticlees
dcterms.sourceLaryngoscopees

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Rapid hemostasis in a sheep model using particles that propel thrombin and tranexamic.pdf
Size:
467.67 KB
Format:
Adobe Portable Document Format
Description:
Texto completo
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Artículos Medicina y Ciencias de la Salud

Implementado por OpenGeek Services