New Perspectives to Improve Mesenchymal Stem Cell Therapies for Drug-Induced Liver Injury

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dc.contributor.authorEzquer, Fernando
dc.contributor.authorHuang, Ya-Lin
dc.contributor.authorEzquer, Marcelo
dc.date.accessioned2022-11-14T20:30:42Z
dc.date.available2022-11-14T20:30:42Z
dc.date.issued2022
dc.description.abstractAbstract: Drug-induced liver injury (DILI) is one of the leading causes of acute liver injury. Many factors may contribute to the susceptibility of patients to this condition, making DILI a global medical problem that has an impact on public health and the pharmaceutical industry. The use of mesenchymal stem cells (MSCs) has been at the forefront of regenerative medicine therapies for many years, including MSCs for the treatment of liver diseases. However, there is currently a huge gap between these experimental approaches and their application in clinical practice. In this concise review, we focus on the pathophysiology of DILI and highlight new experimental approaches conceived to improve cell-based therapy by the in vitro preconditioning of MSCs and/or the use of cell-free products as treatment for this liver condition. Finally, we discuss the advantages of new approaches, but also the current challenges that must be addressed in order to develop safer and more effective procedures that will allow cell-based therapies to reach clinical practice, enhancing the quality of life and prolonging the survival time of patients with DILI.es
dc.description.versionVersión publicadaes
dc.identifier.citation: Ezquer, F.; Huang, Y.-L.; Ezquer, M. New Perspectives to Improve Mesenchymal Stem Cell Therapies for Drug-Induced Liver Injury. Int. J. Mol. Sci. 2022, 23, 2669. https://doi.org/10.3390/ijms23052669es
dc.identifier.urihttps://doi.org/10.3390/ijms23052669es
dc.identifier.urihttp://hdl.handle.net/11447/6663
dc.language.isoenes
dc.subjectMesenchymal stem cellses
dc.subjectDrug-induced liver injuryes
dc.subjectSecretomees
dc.subjectExosomeses
dc.subjectCell therapyes
dc.titleNew Perspectives to Improve Mesenchymal Stem Cell Therapies for Drug-Induced Liver Injuryes
dc.typeArticlees
dcterms.sourceInternational Journal of Molecular Scienceses

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