Gilz-Activin A as a Novel Signaling Axis Orchestrating Mesenchymal Stem Cell and Th17 Cell Interplay

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dc.contributor.authorLuz-Crawford, Patricia
dc.contributor.authorEspinosa-Carrasco, Gabriel
dc.contributor.authorIpseiz, Natacha
dc.contributor.authorContreras, Rafael
dc.contributor.authorTejedor, Gautier
dc.contributor.authorMedina, Daniel A.
dc.contributor.authorVega, Ana María
dc.contributor.authorNgo, Devi
dc.contributor.authorMorand, Eric F.
dc.contributor.authorPène, Jérôme
dc.contributor.authorHernandez, Javier
dc.contributor.authorJorgensen, Christian
dc.contributor.authorDjouad, Farida
dc.date.accessioned2022-05-26T20:32:28Z
dc.date.available2022-05-26T20:32:28Z
dc.date.issued2018
dc.description.abstractMesenchymal stem cells (MSC) are highly immunosuppressive cells able to reduce chronic inflammation through the active release of mediators. Recently, we showed that glucocorticoid-induced leucine zipper (Gilz) expression by MSC is involved in their therapeutic effect by promoting the generation of regulatory T cells. However, the mechanisms underlying this pivotal role of Gilz remain elusive. Methods and Results In this study, we have uncovered evidence that Gilz modulates the phenotype and function of Th1 and Th17 cells likely by upregulating the level of Activin A and NO2 secreted by MSC. Adoptive transfer experiments sustained this Gilz-dependent suppressive effect of MSC on Th1 and Th17 cell functions. In immunoregulatory MSC, obtained by priming with IFN-γ and TNF-α, Gilz was translocated to the nucleus and bound to the promoters of inos and Activin βA to induce their expression. The increased expression of Activin A directly impacted on Th17 cells fate by repressing their differentiation program through the activation of Smad3/2 and enhancing IL-10 production. Conclusion Our results reveal how Gilz controls inos and Activin βA gene expression to ultimately assign immunoregulatory status to MSC able to repress the pathogenic Th17 cell differentiation program and uncover Activin A as a novel mediator of MSC in this process.es
dc.description.versionVersión Publicadaes
dc.identifier.citationLuz-Crawford P, Espinosa-Carrasco G, Ipseiz N, Contreras R, Tejedor G, Medina DA, Vega-Letter AM, Ngo D, Morand EF, Pène J, Hernandez J, Jorgensen C, Djouad F. Gilz-Activin A as a Novel Signaling Axis Orchestrating Mesenchymal Stem Cell and Th17 Cell Interplay. Theranostics. 2018 Jan 1;8(3):846-859. doi: 10.7150/thno.21793es
dc.identifier.urihttps://doi.org/10.7150/thno.21793es
dc.identifier.urihttp://hdl.handle.net/11447/6148
dc.language.isoenes
dc.subjectActivin Aes
dc.subjectGilzes
dc.subjectImmunosuppressiones
dc.subjectMesenchymal Stem Cellses
dc.subjectTh17 cellses
dc.titleGilz-Activin A as a Novel Signaling Axis Orchestrating Mesenchymal Stem Cell and Th17 Cell Interplayes
dc.typeArticlees
dcterms.sourceTheranosticses

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