ADAR1 Transcriptome editing promotes breast cancer progression through the regulation of cell cycle and DNA damage response

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dc.contributor.authorSagredo, Eduardo
dc.contributor.authorSagredo, Alfredo
dc.contributor.authorBlanco, Alejandro
dc.contributor.authorRojas, Pamela
dc.contributor.authorRivas, Solange
dc.contributor.authorAssar, Rodrigo
dc.contributor.authorPérez, Paola
dc.contributor.authorMarcelain, Katherine
dc.contributor.authorArmisén, Ricardo
dc.date.accessioned2021-01-14T16:33:43Z
dc.date.available2021-01-14T16:33:43Z
dc.date.issued2020
dc.descriptionCentro de Genética y Genómica - ICIMes
dc.description.abstractRNA editing has emerged as a novel mechanism in cancer progression. The double stranded RNA-specific adenosine deaminase (ADAR) modifies the expression of an important proportion of genes involved in cell cycle control, DNA damage response (DDR) and transcriptional processing, suggesting an important role of ADAR in transcriptome regulation. Despite the phenotypic implications of ADAR deregulation in several cancer models, the role of ADAR on DDR and proliferation in breast cancer has not been fully addressed. Here, we show that ADAR expression correlates significantly with clinical outcomes and DDR, cell cycle and proliferation mRNAs of previously reported edited transcripts in breast cancer patients. ADAR's knock-down in a breast cancer cell line produces stability changes of mRNAs involved in DDR and DNA replication. Breast cancer cells with reduced levels of ADAR show a decreased viability and an increase in apoptosis, displaying a significant decrease of their DDR activation, compared to control cells. These results suggest that ADAR plays an important role in breast cancer progression through the regulation of mRNA stability and expression of those genes involved in proliferation and DDR impacting the viability of breast cancer cells.es
dc.identifier.citationSagredo EA, Sagredo AI, Blanco A, Rojas De Santiago P, Rivas S, Assar R, Pérez P, Marcelain K, Armisén R. ADAR1 Transcriptome editing promotes breast cancer progression through the regulation of cell cycle and DNA damage response. Biochim Biophys Acta Mol Cell Res. 2020 Aug;1867(8):118716. doi: 10.1016/j.bbamcr.2020.118716. Epub 2020 Apr 8. PMID: 32275931.es
dc.identifier.urihttps://doi.org/10.1016/j.bbamcr.2020.118716es
dc.identifier.urihttp://hdl.handle.net/11447/3720
dc.language.isoenes
dc.publisherElsevier B.V.es
dc.subjectBreast canceres
dc.subjectDNA damage responsees
dc.subjectProliferationes
dc.subjectRNA editinges
dc.subjectRNA stabilityes
dc.titleADAR1 Transcriptome editing promotes breast cancer progression through the regulation of cell cycle and DNA damage responsees
dc.typeArticlees

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