The incidence of non-affective psychotic disorders in Chile between 2005 and 2018: results from a national register of over 30 000 cases

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dc.contributor.authorGonzález-Valderrama, Alfonso
dc.contributor.authorJongsma, Hannah E.
dc.contributor.authorMena, Cristián
dc.contributor.authorCastañeda, Carmen Paz
dc.contributor.authorNachar, Rubén
dc.contributor.authorUndurraga, Juan
dc.contributor.authorCrossley, Nicolás
dc.contributor.authorAceituno, David
dc.contributor.authorIruretagoyena, Bárbara
dc.contributor.authorGallardo, Carlos
dc.contributor.authorMondaca, Pilar
dc.contributor.authorMonje, Matías
dc.contributor.authorIrarrazaval, Matías
dc.contributor.authorZavala, Cynthia
dc.contributor.authorValmaggia, Lucia
dc.contributor.authorKirkbride, James B.
dc.date.accessioned2021-08-09T21:53:52Z
dc.date.available2021-08-09T21:53:52Z
dc.date.issued2020-08
dc.description.abstractBackground. Evidence suggests the incidence of non-affective psychotic disorders (NAPDs) varies across persons and places, but data from the Global South is scarce. We aimed to estimate the treated incidence of NAPD in Chile, and variance by person, place and time. Methods. We used national register data from Chile including all people, 10–65 years, with the first episode of NAPD (International Classification of Diseases, Tenth Revision: F20– F29) between 1 January 2005 and 29 August 2018. Denominators were estimated from Chilean National Census data. Our main outcome was treated incidence of NAPD and age group, sex, calendar year and regional-level population density, multidimensional poverty and latitude were exposures of interest. Results. We identified 32358 NAPD cases [12136 (39.5%) women; median age-at-first- contact: 24 years (interquartile range 18–39 years)] during 171.1 million person-years [crude incidence: 18.9 per 100 000 person-years; 95% confidence interval (CI) 18.7–19.1]. Multilevel Poisson regression identified a strong age–sex interaction in incidence, with rates peaking in men (57.6 per 100 000 person-years; 95% CI 56.0–59.2) and women (29.5 per 100 000 person-years; 95% CI 28.4–30.7) between 15 and 19 years old. Rates also decreased (non-linearly) over time for women, but not men. We observed a non-linear association with multidimensional poverty and latitude, with the highest rates in the poorest regions and those immediately south of Santiago; no association with regional population density was observed. Conclusion. Our findings inform the aetiology of NAPDs, replicating typical associations with age, sex and multidimensional poverty in a Global South context. The absence of asso- ciation with population density suggests this risk may be context-dependent.es
dc.identifier.citationPsychological Medicine, 2020es
dc.identifier.urihttps://doi.org/10.1017/S0033291720002664es
dc.identifier.urihttp://hdl.handle.net/11447/4270
dc.language.isoenes
dc.subjectCase registeres
dc.subjectChilees
dc.subjectIncidencees
dc.subjectNon-affective psychosises
dc.subjectSouth Americaes
dc.titleThe incidence of non-affective psychotic disorders in Chile between 2005 and 2018: results from a national register of over 30 000 caseses
dc.typeArticlees

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