Prevalence and distribution of peripheral musculoskeletal manifestations in spondyloarthritis including psoriatic arthritis: results of the worldwide, cross-sectional ASASPerSpA study

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dc.contributor.authorLópez, Clementina
dc.contributor.authorMolto, Anna
dc.contributor.authorSieper, Joachim
dc.contributor.authorDuruöz, Tuncay
dc.contributor.authorKiltz, Uta
dc.contributor.authorElzorkany, Bassel
dc.contributor.authorHajjaj, Najia
dc.contributor.authorBurgos, Ruben
dc.contributor.authorMaldonado, José
dc.contributor.authorZiade, Nelly
dc.contributor.authorGavali, Meghna
dc.contributor.authorNavarro, Victoria
dc.contributor.authorLuo, Shue
dc.contributor.authorMont, Sara
dc.contributor.authorTae, Kim
dc.contributor.authorKishimoto, Mitsumasa
dc.contributor.authorSantos, Pimentel
dc.contributor.authorGu, Jieruo
dc.contributor.authorSchiotis, Ruxandra
dc.contributor.authorVan Gaalen, Floris
dc.contributor.authorGeher, Pál
dc.contributor.authorMagrey, Marina
dc.contributor.authorIbáñez, Sebastián
dc.contributor.authorBautista, Wilson
dc.contributor.authorMaksymowych, Walter
dc.contributor.authorMachado, Pedro
dc.contributor.authorLandewé, Robert
dc.contributor.authorVan der Heijde, Desirée
dc.contributor.authorDougados, Maxime
dc.date.accessioned2022-04-05T17:07:55Z
dc.date.available2022-04-05T17:07:55Z
dc.date.issued2021
dc.description.abstractObjectives: To characterise peripheral musculoskeletal involvement in patients with spondyloarthritis (SpA) including psoriatic arthritis (PsA), across the world. Methods: Cross-sectional study with 24 participating countries. Patients with a diagnosis of axial SpA (axSpA), peripheral SpA (pSpA) or PsA according to their rheumatologist were included. The investigators were asked which diagnosis out of a list of six (axSpA, PsA, pSpA, inflammatory bowel disease-associated SpA, reactive arthritis or juvenile SpA (Juv-SpA)) fitted the patient best. Peripheral manifestations (ie, peripheral joint disease, enthesitis, dactylitis and root joint disease), their localisation and treatments were evaluated. Results: A total of 4465 patients were included (61% men, mean age 44.5 years) from four geographic areas: Latin America (n=538), Europe plus North America (n=1677), Asia (n=975) and the Middle East plus North Africa (n=1275). Of those, 78% had ever suffered from at least one peripheral musculoskeletal manifestation; 57% had peripheral joint disease, 44% had enthesitis and 15% had dactylitis. Latin American had far more often peripheral joint disease (80%) than patients from other areas. Patients with PsA had predominantly upper limb and small joint involvement (52%).Hip and shoulder involvement was found in 34% of patients. The prevalence of enthesitis ranged between 41% in patients with axSpA and 65% in patients with Juv-SpA. Dactylitis was most frequent among patients with PsA (37%). Conclusion: These results suggest that all peripheral features can be found in all subtypes of SpA, and that differences are quantitative rather than qualitative. In a high proportion of patients, axial and peripheral manifestations coincided. These findings reconfirm SpA clinical subtypes are descendants of the same underlying disease, called SpA.es
dc.description.versionVersión publicada
dc.identifier.citationLópez-Medina C, Molto A, Sieper J, Duruöz T, Kiltz U, Elzorkany B, Hajjaj-Hassouni N, Burgos-Vargas R, Maldonado-Cocco J, Ziade N, Gavali M, Navarro-Compan V, Luo SF, Monti S, Tae-Jong K, Kishimoto M, Pimentel-Santos FM, Gu J, Schiotis R, van Gaalen FA, Geher P, Magrey M, Ibáñez Vodnizza SE, Bautista-Molano W, Maksymowych W, Machado PM, Landewé R, van der Heijde D, Dougados M. Prevalence and distribution of peripheral musculoskeletal manifestations in spondyloarthritis including psoriatic arthritis: results of the worldwide, cross-sectional ASAS-PerSpA study. RMD Open. 2021 Jan;7(1):e001450. doi: 10.1136/rmdopen-2020-001450es
dc.identifier.urihttps://doi.org/10.1136/rmdopen-2020-001450es
dc.identifier.urihttp://hdl.handle.net/11447/5933
dc.language.isoenes
dc.subjectAnkylosinges
dc.subjectArthritises
dc.subjectJuvenilees
dc.subjectPsoriatices
dc.subjectSpondylitises
dc.titlePrevalence and distribution of peripheral musculoskeletal manifestations in spondyloarthritis including psoriatic arthritis: results of the worldwide, cross-sectional ASASPerSpA studyes
dc.typeArticlees
dcterms.sourceRMD openes

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