Proteinuria in Hantavirus Cardiopulmonary Syndrome: A Frequent Finding Linked To Mortality

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dc.contributor.authorLópez, René
dc.contributor.authorEspinoza, Mauricio
dc.contributor.authorGraf, Jerónimo
dc.contributor.authorMertz, Gregory
dc.contributor.authorFerrés, Marcela
dc.contributor.authorCalvo, Mario
dc.contributor.authorVial, Cecilia
dc.contributor.authorVial, Pablo
dc.contributor.authorHantavirus Study Group in Chile
dc.date.accessioned2022-03-30T15:46:02Z
dc.date.available2022-03-30T15:46:02Z
dc.date.issued2021
dc.description.abstractObjectives: To determine the relative frequency and prognosis value of proteinuria in hantavirus cardiopulmonary syndrome (HCPS) due to Andes virus. Methods: This observational analytical study prospectively obtained data from patients admitted to 12 health centers in nine Chilean cities between 2001 and 2018. Only patients with confirmed Andes virus HCPS and laboratory characterization that included qualitative proteinuria determination at admission were considered. Results: The database involved 175 patients, 95 of them had a measurement of urine protein at the time of hospital admission. They were mainly male (71%) and the median age was 35 [22-47] years. Median duration of the febrile prodromal time was 5 [4-7] days. Hospital length of stay and hospital mortality rate were 10 [7-14] days and 21.1%, respectively. Seventy-three patients (77%) were identified with proteinuria at admission, which was associated with increased mortality rate (26% versus 5%, p=0.036) and the relative risk was 1.3 [1.1-1.6], p=0.002. Conclusions: Proteinuria is a frequent finding in patients with HCPS, which is associated with a higher mortality rate.es
dc.description.versionVersión publicadaes
dc.identifier.urihttps://doi.org/10.1016/j.ijid.2021.07.026es
dc.identifier.urihttp://hdl.handle.net/11447/5864
dc.language.isoenes
dc.subjectAndes viruses
dc.subjectHantavirus cardiopulmonary syndromees
dc.subjectMortalityes
dc.subjectProteinuriaes
dc.titleProteinuria in Hantavirus Cardiopulmonary Syndrome: A Frequent Finding Linked To Mortalityes
dc.typeArticlees
dcterms.sourcenternational journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseaseses

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