Caracterización de tumores secretores de hormona de crecimiento de acuerdo al patrón granular y su rol en el pronóstico

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dc.contributor.authorValenzuela, Felipe
dc.contributor.authorVillanueva, Pablo
dc.contributor.authorRojas, David
dc.contributor.authorGejman, Roger
dc.contributor.authorHuete, Isidro
dc.contributor.authorZunino, Romina
dc.contributor.authorDíaz, René
dc.contributor.authorWohllk, Nelson
dc.contributor.authorTissera, Claudia
dc.contributor.authorCarrasco, Carmen
dc.date.accessioned2022-07-12T15:10:02Z
dc.date.available2022-07-12T15:10:02Z
dc.date.issued2019
dc.description.abstractBackground: Classification of growth hormone (GH) - secreting tumors by the granular pattern might predict their clinical behavior in acromegalic patients. There are several other prognostic factors. Aim: To compare the features at presentation and cure rates of patients with GH secreting tumors according to the granular pattern, and to define independent prognostic factors for surgical treatment in these patients. Material and Methods: A retrospective, observational study of 85 active acromegalic patients surgically treated in two medical centers. Results: Seventy-four patients (87%) were classified as having densely granulated (DG) and 11 (13%) as sparsely granulated (SG) tumors. The latter were less active biochemically, had a higher rate of macroadenoma and cavernous sinus invasion and had a lower rate of biochemical cure than the DG group. Several characteristics were associated with disease persistence but only age (Odds ratio (OR) = 0.93) and cavernous sinus invasion (OR = 21.7) were independently associated in the logistic regression model. Conclusions: The sparsely granulated pattern is associated with a more aggressive behavior, but the main determinants of prognosis are age and cavernous sinus invasion.es
dc.description.versionVersión publicadaes
dc.identifier.citationValenzuela F, Villanueva P, Rojas Z D, Gejman R, Huete I, Zunino R, Díaz RE, Wohllk N, Tissera C, Carrasco CA. Caracterización de tumores secretores de hormona de crecimiento de acuerdo al patrón granular y su rol en el pronóstico [Prognostic value of granular pattern of growth hormone secreting tumors]. Rev Med Chil. 2019 Jul;147(7):852-859. Spanish. doi:10.4067/S0034-98872019000700852es
dc.identifier.urihttps://doi.org/10.4067/S0034-98872019000700852es
dc.identifier.urihttp://hdl.handle.net/11447/6352
dc.language.isoeses
dc.subjectAcromegalyes
dc.subjectGrowth Hormone-Secreting Pituitary Adenomaes
dc.subjectImmunohistochemistryes
dc.subjectPathologyes
dc.titleCaracterización de tumores secretores de hormona de crecimiento de acuerdo al patrón granular y su rol en el pronósticoes
dc.title.alternativePrognostic value of granular pattern of growth hormone secreting tumorses
dc.typeArticlees
dcterms.sourceRevista Médica de Chilees

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