Exosome-like vesicles in Apis mellifera bee pollen, honey and royal jelly contribute to their antibacterial and pro-regenerative activity

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dc.contributor.authorSchuh, Christina
dc.contributor.authorAguayo, Sebastian
dc.contributor.authorZavala, Gabriela
dc.contributor.authorKhoury, Maroun
dc.date.accessioned2019-11-26T19:29:14Z
dc.date.available2019-11-26T19:29:14Z
dc.date.issued2019
dc.description.abstractMicrovesicles are key players in cellular communication. As glandular secretions present a rich source of active exosomes, we hypothesized that exosome-like vesicles are present in Apis mellifera hypopharyngeal gland secretomal products (honey, royal jelly and bee pollen), and participate in their known antibacterial and pro-regenerative effects. We developed an isolation protocol based on serial centrifugation and ultracentrifugation steps and demonstrated the presence of protein-containing exosome-like vesicles in all three bee-derived products. Assessing their antibacterial properties, we found that exosome-like vesicles had bacteriostatic, bactericidal and biofilm-inhibiting effects on Staphylococcus aureus. Furthermore, we demonstrated that mesenchymal stem cells (MSCs) internalize bee-derived exosome- like vesicles and that these vesicles influence the migration potential of the MSCs. In an in vitro wound-healing assay, honey and royal jelly exosome-like vesicles increased migration of human MSCs, demonstrating their inter-kingdom activity. In summary, we have discovered exosome-like vesicles as a new, active compound in bee pollen, honey and royal jelly.
dc.format.extent7 p.
dc.identifier.citationJournal of Experimental Biology, 2019, 222, jeb208702
dc.identifier.urihttp://hdl.handle.net/11447/2863
dc.language.isoen
dc.subjectMicrovesicle
dc.subjectApis mellifera
dc.subjectBactericide
dc.subjectIntercellular communication
dc.subjectInter-kingdom communication
dc.titleExosome-like vesicles in Apis mellifera bee pollen, honey and royal jelly contribute to their antibacterial and pro-regenerative activity
dc.typeArticle

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