Antimicrobial Susceptibility Testing for Enterococci

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dc.contributor.authorKhan, Ayesha
dc.contributor.authorMiller, William
dc.contributor.authorAxell, Dierdre
dc.contributor.authorMunita, José
dc.contributor.authorAriasb, Cesar
dc.date.accessioned2022-11-17T17:07:38Z
dc.date.available2022-11-17T17:07:38Z
dc.date.issued2022
dc.description.abstractEnterococci are major, recalcitrant nosocomial pathogens with a wide repertoire of intrinsic and acquired resistance determinants and the potential of developing resistance to all clinically available antimicrobials. As such, multidrug-resistant enterococci are considered a serious public health threat. Due to limited treatment options and rapid emergence of resistance to all novel agents, the clinical microbiology laboratory plays a critical role in deploying accurate, reproducible, and feasible antimicrobial susceptibility testing methods to guide appropriate treatment of patients with deep-seated enterococcal infections. In this review, we provide an overview of the advantages and disadvantages of existing manual and automated methods that test susceptibility of Enterococcus faecium and Enterococcus faecalis to β-lactams, aminoglycosides, vancomycin, lipoglycopeptides, oxazolidinones, novel tetracycline-derivatives, and daptomycin. We also identify unique problems and gaps with the performance and clinical utility of antimicrobial susceptibility testing for enterococci, provide recommendations for clinical laboratories to circumvent select problems, and address potential future innovations that can bridge major gaps in susceptibility testing.es
dc.description.versionVersión publicadaes
dc.identifier.citationKhan A, Miller WR, Axell-House D, Munita JM, Arias CA. Antimicrobial Susceptibility Testing for Enterococci. J Clin Microbiol. 2022 Sep 21;60(9):e0084321. doi: 10.1128/jcm.00843-21es
dc.identifier.urihttps://doi.org/10.1128/jcm.00843-21es
dc.identifier.urihttp://hdl.handle.net/11447/6687
dc.language.isoenes
dc.subjectEnterococcuses
dc.subjectAntibiotic resistancees
dc.subjectAntimicrobial activityes
dc.subjectAntimicrobial agentses
dc.subjectClinical methodses
dc.subjectDiagnosticses
dc.subjectGram-positive bacteriaes
dc.subjectHospital infectionses
dc.subjectMultidrug resistancees
dc.subjectSusceptibility testinges
dc.titleAntimicrobial Susceptibility Testing for Enterococcies
dc.typeArticlees
dcterms.sourceJournal of clinical microbiologyes

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