A changing etiologic scenario in liver transplantation for hepatocellular carcinoma in a multicenter cohort study from Latin America

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dc.contributor.authorPinero, Federico
dc.contributor.authorCosta, Paulo
dc.contributor.authorLongatto Boteon, Yuri
dc.contributor.authorHoyos Duque, Sergio
dc.contributor.authorMarciano, Sebastián
dc.contributor.authorAnders, Margarita
dc.contributor.authorVaróng, Adriana
dc.contributor.authorZerega, Alina
dc.contributor.authorPoniachik, Jaime
dc.contributor.authorSoza, Alejandro
dc.contributor.authorPadilla Machaca, Martín
dc.contributor.authorMenéndez, Josemaría
dc.contributor.authorZapata, Rodrigo
dc.contributor.authorVilatoba, Mario
dc.contributor.authorMuñoz, Linda
dc.contributor.authorMaraschio, Martín
dc.contributor.authorPodestá, Luis G.
dc.contributor.authorMcCormack, Lucas
dc.contributor.authorGadano, Adrian
dc.contributor.authorBoinc, Ilka S.F. Fatima
dc.contributor.authorGarcía, Parente
dc.contributor.authorSilva, Marcelo
dc.contributor.authorOn behalf of the Latin American Liver Research, Education, Awareness Network (LALREAN)
dc.date.accessioned2022-04-27T21:55:02Z
dc.date.available2022-04-27T21:55:02Z
dc.date.issued2018
dc.description.abstractBackground and aim: Non-alcoholic fatty liver disease (NAFLD) is an increasing cause of hepatocellular carcinoma (HCC) and liver transplantation (LT). Our study focused on changing trendsof liver related HCC etiologies during the last years in Latin America. Methods: From a cohort of 2761 consecutive adult LT patients between 2005 and 2012 in 17 different centers, 435 with HCC were included. Different periods including years 2005—2006, 2007—2008, 2009—2010 and 2011—2012 were considered. Etiology of liver disease was confirmed in the explant. Results: Participating LT centers per country included 2 from Brazil (n = 191), 5 transplant programs from Argentina (n = 98), 2 from Colombia (n = 65), 4 from Chile (n = 49), 2 from Mexico (n = 12), and 1 from Peru (n = 11) and Uruguay (n = 9). Chronic hepatitis C infection was the leading cause of HCC in the overall cohort (37%), followed by HBV (25%) and alcoholic liver disease (17%). NAFLD and cryptogenic cirrhosis accounted for 6% and 7%, respectively. While HCV decreased from 48% in 2005—06 to 26% in 2011—12, NAFLD increased from 1.8% to 12.8% during the same period, accounting for the third cause of HCC. This represented a 6-fold increase in NAFLD-HCC, whereas HCV had a 2-fold decrease. Patients with NAFLD were older, had lower pre-LT serum AFP values and similar 5-year survival and recurrence rates than non-NAFLD. Conclusion: There might be a global changing figure regarding etiologies of HCC in Latin America. This epidemiological change on the incidence of HCC in the world, although it has been reported, should still be confirmed in prospective studies.es
dc.description.versionVersión Publicadaes
dc.identifier.citationiñero F, Costa P, Boteon YL, Duque SH, Marciano S, Anders M, Varón A, Zerega A, Poniachik J, Soza A, Padilla Machaca M, Menéndez J, Zapata R, Vilatoba M, Muñoz L, Maraschio M, Podestá LG, McCormack L, Gadano A, Boin ISFF, García P, Silva M; Latin American Liver Research, Education, Awareness Network (LALREAN). A changing etiologic scenario in liver transplantation for hepatocellular carcinoma in a multicenter cohort study from Latin America. Clin Res Hepatol Gastroenterol. 2018 Oct;42(5):443-452. doi: 10.1016/j.clinre.2018.03.014.es
dc.identifier.urihttps://doi.org/10.1016/j.clinre.2018.03.014es
dc.identifier.urihttp://hdl.handle.net/11447/6029
dc.language.isoenes
dc.subjectEpidemiologyes
dc.subjectLiver canceres
dc.subjectSteatohepatitises
dc.subjectTransplantationes
dc.titleA changing etiologic scenario in liver transplantation for hepatocellular carcinoma in a multicenter cohort study from Latin Americaes
dc.typeArticlees
dcterms.sourceClinics and Research in Hepatology and Gastroenterologyes

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