A Molecular Stratification of Chilean Gastric Cancer Patients with Potential Clinical Applicability

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dc.contributor.authorPinto, Mauricio
dc.contributor.authorCórdova-Delgado, Miguel
dc.contributor.authorRetamal, Ignacio
dc.contributor.authorMuñoz-Medel, Matías
dc.contributor.authorBravo, Loreto
dc.contributor.authorDurán, Doris
dc.contributor.authorVillanueva, Francisco
dc.contributor.authorSánchez, César
dc.contributor.authorAcevedo, Francisco
dc.contributor.authorMondaca, Sebastián
dc.contributor.authorÉrica, Koch
dc.contributor.authorIbáñez, Carolina
dc.contributor.authorGalindo, Héctor
dc.contributor.authorMadrid, Jorge
dc.contributor.authorNervi, Bruno
dc.contributor.authorPeña, José
dc.contributor.authorTorres, Javiera
dc.contributor.authorGarrido, Marcelo
dc.contributor.authorOwen, Gareth I.
dc.contributor.authorCorvalán, Alejandro H.
dc.contributor.authorArmisén, Ricardo
dc.date.accessioned2021-01-14T16:24:09Z
dc.date.available2021-01-14T16:24:09Z
dc.date.issued2020
dc.descriptionCentro Genética y Genómica - ICIMes
dc.description.abstractGastric cancer (GC) is a complex and heterogeneous disease. In recent decades, The Cancer Genome Atlas (TCGA) and the Asian Cancer Research Group (ACRG) defined GC molecular subtypes. Unfortunately, these systems require high-cost and complex techniques and consequently their impact in the clinic has remained limited. Additionally, most of these studies are based on European, Asian, or North American GC cohorts. Herein, we report a molecular classification of Chilean GC patients into five subtypes, based on immunohistochemical (IHC) and in situ hybridization (ISH) methods. These were Epstein–Barr virus positive (EBV+), mismatch repair-deficient (MMR-D), epithelial to mesenchymal transition (EMT)-like, and accumulated (p53+) or undetected p53 (p53−). Given its lower costs this system has the potential for clinical applicability. Our results confirm relevant molecular alterations previously reported by TCGA and ACRG. We confirm EBV+ and MMR-D patients had the best prognosis and could be candidates for immunotherapy. Conversely, EMT-like displayed the poorest prognosis; our data suggest FGFR2 or KRAS could serve as potential actionable targets for these patients. Finally, we propose a low-cost step-by-step stratification system for GC patients. To the best of our knowledge, this is the first Latin American report on a molecular classification for GC. Pending further validation, this stratification system could be implemented into the routine clinices
dc.identifier.citationPinto MP, Córdova-Delgado M, Retamal IN, Muñoz-Medel M, Bravo ML, Durán D, Villanueva F, Sanchez C, Acevedo F, Mondaca S, Koch É, Ibañez C, Galindo H, Madrid J, Nervi B, Peña J, Torres J, Garrido M. A Molecular Stratification of Chilean Gastric Cancer Patients with Potential Clinical Applicability. Cancers (Basel). 2020 Jul 10;12(7):1863. doi: 10.3390/cancers12071863. PMID: 32664343; PMCID: PMC7408697.es
dc.identifier.urihttps://doi.org/10.3390/cancers12071863es
dc.identifier.urihttp://hdl.handle.net/11447/3719
dc.language.isoenes
dc.publisherMDPI, Basel Sz.es
dc.subjectEpstein–Barr viruses
dc.subjectGastric canceres
dc.subjectMolecular classificationes
dc.subjectMolecular subtypeses
dc.subjectTargeted therapyes
dc.titleA Molecular Stratification of Chilean Gastric Cancer Patients with Potential Clinical Applicabilityes
dc.typeArticlees

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