New Perspectives on Antimicrobial Agents: Long-Acting Lipoglycopeptides

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dc.contributor.authorTran, Truc
dc.contributor.authorGomez, Sara
dc.contributor.authorAitken, Samuel
dc.contributor.authorButler, Susan
dc.contributor.authorSoriano, Alex
dc.contributor.authorWerth, Brian
dc.contributor.authorMunita, José
dc.date.accessioned2022-11-17T16:02:18Z
dc.date.available2022-11-17T16:02:18Z
dc.date.issued2022
dc.description.abstractThe long-acting lipoglycopeptides (LGPs) dalbavancin and oritavancin are semisynthetic antimicrobials with broad and potent activity against Gram-positive bacterial pathogens. While they are approved by the Food and Drug Administration for acute bacterial skin and soft tissue infections, their pharmacological properties suggest a potential role of these agents for the treatment of deep-seated and severe infections, such as bloodstream and bone and joint infections. The use of these antimicrobials is particularly appealing when prolonged therapy, early discharge, and avoidance of long-term intravascular catheter access are desirable or when multidrug-resistant bacteria are suspected. This review describes the current evidence for the use of oritavancin and dalbavancin in the treatment of invasive infections, as well as the hurdles that are preventing their optimal use. Moreover, this review discusses the current knowledge gaps that need to be filled to understand the potential role of LGPs in highly needed clinical scenarios and the ongoing clinical studies that aim to address these voids in the upcoming years.es
dc.description.versionVersión publicadaes
dc.identifier.citationTran TT, Gomez Villegas S, Aitken SL, Butler-Wu SM, Soriano A, Werth BJ, Munita JM. New Perspectives on Antimicrobial Agents: Long-Acting Lipoglycopeptides. Antimicrob Agents Chemother. 2022 Jun 21;66(6):e0261420. doi: 10.1128/aac.02614-20es
dc.identifier.urihttps://doi.org/10.1128/aac.02614-20es
dc.identifier.urihttp://hdl.handle.net/11447/6685
dc.language.isoenes
dc.subjectDalbavancines
dc.subjectLipoglycopeptidees
dc.subjectOritavancines
dc.titleNew Perspectives on Antimicrobial Agents: Long-Acting Lipoglycopeptideses
dc.typeArticlees
dcterms.sourceAntimicrobial agents and chemotherapyes

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