Intraventricular Bleeding and Hematoma Size as Predictors of Infection Development in Intracerebral Hemorrhage: A Prospective Cohort Study

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dc.contributor.authorVial Undurraga, Felipe
dc.contributor.authorBrunser, Alejandro
dc.contributor.authorLavados, Pablo
dc.contributor.authorIllanes, Sergio
dc.date.accessioned2017-08-11T19:27:03Z
dc.date.available2017-08-11T19:27:03Z
dc.date.issued2016
dc.description.abstractBACKGROUND: Acute intracerebral hemorrhage (ICH) is associated with increased susceptibility to bacterial infection. The physiopathology of this phenomenon is not very clear. We conducted a prospective observational study investigating the correlation and independent predictors of infections in patients with ICH. PATIENTS AND METHODS: Patients admitted between April 1997 and June 2013 with ICH diagnosis were evaluated for inclusion and exclusion criteria. RESULTS: Two hundred twenty-two patients were included in this study. Ninety four patients (42.6%) presented with an infection during hospitalization being more common than pneumonia (30%) and urinary tract infections (14%). Intraventricular hemorrhage (IVH) (95% confidence interval [CI], 62.7% versus 39.3%; P < .001) and higher ICH score (95% CI, 2.31% versus 1.67%; P = .0014) were more common in patients who had infections. We found the following risk factors for having an infection in patients with ICH: IVH (odds ratio [OR] 2.3; 95% IC, 1.3-4.1), each point of ICH score (OR 1.3; 95% CI, 1.1-1.6), and having a hematoma volume larger than 30 cc (OR 2.0; 95% CI, 1.1-3.5). The localization of the hematoma was not found to be relevant. CONCLUSIONS: ICH score, size of the hematoma, and presence of IVH are independent risk factors for having an infection after ICH.
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dc.identifier.citationVial F, Brunser A, Lavados P, Illanes S. Intraventricular Bleeding and Hematoma Size as Predictors of Infection Development in Intracerebral Hemorrhage: A Prospective Cohort Study. J Stroke Cerebrovasc Dis. 2016 Nov;25(11):2708-2711.
dc.identifier.urihttp://hdl.handle.net/11447/1570
dc.identifier.urihttp://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2016.07.020
dc.language.isoen_US
dc.publisherElsevier
dc.subjectIntracerebral hemorrhage
dc.subjectICH
dc.subjecthemorrhagic stroke
dc.subjectimmune response
dc.subjectinfections
dc.subjectstroke inflammation
dc.titleIntraventricular Bleeding and Hematoma Size as Predictors of Infection Development in Intracerebral Hemorrhage: A Prospective Cohort Study
dc.typeArtículo

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