Genetic Variants in pre-miR-146a, pre-miR-499, pre-miR-125a, pre-miR-605, and pri-miR-182 Are Associated with Breast Cancer Susceptibility in a South American Population

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dc.contributor.authorMorales, Sebastián
dc.contributor.authorDe Mayo, Tomas
dc.contributor.authorGulppi, Felipe Andrés
dc.contributor.authorGonzalez-Hormazabal, Patricio
dc.contributor.authorCarrasco, Valentina
dc.contributor.authorReyes, José Miguel
dc.contributor.authorGómez, Fernando
dc.contributor.authorWaugh, Enrique
dc.contributor.authorJara, Lilian
dc.date.accessioned2021-08-30T21:01:25Z
dc.date.available2021-08-30T21:01:25Z
dc.date.issued2018
dc.description.abstractAbstract: Breast cancer (BC) is one of themost frequent tumors affecting women worldwide. microRNAs (miRNAs) single-nucleotide polymorphisms (SNPs) likely contribute to BC susceptibility. We evaluated the association of five SNPs with BC risk in non-carriers of the BRCA1/2-mutation from a South American population. The SNPs were genotyped in 440 Chilean BRCA1/2-negative BC cases and 1048 controls. Our data do not support an association between rs2910164:G>C or rs3746444:A>G and BC risk. The rs12975333:G>T is monomorphic in the Chilean population. The pre-miR-605 rs2043556-C allele was associated with a decreased risk of BC, both in patients with a strong family history of BC and in early-onset non-familial BC (Odds ratio (OR) = 0.5 [95% confidence interval (CI) 0.4–0.9] p = 0.006 and OR = 0.6 [95% CI 0.5–0.9] p = 0.02, respectively). The rs4541843-T allele is associated with increased risk of familial BC. This is the first association study on rs4541843 and BC risk. Previously, we showed that the TOX3-rs3803662:C>T was significantly associated with increased risk of familial BC. Given that TOX3 mRNA is a target of miR-182, and that both the TOX3 rs3803662-T and pri-miR-182 rs4541843-T alleles are associated with increased BC risk, we evaluated their combined effect. Risk of familial BC increased in a dose-dependent manner with the number of risk alleles (p-trend = 0.0005), indicating an additive effect.es
dc.identifier.citationGenes 2018, 9, 427es
dc.identifier.urihttps://doi.org/10.3390/genes9090427es
dc.identifier.urihttp://hdl.handle.net/11447/4536
dc.language.isoenes
dc.subjectFamilial breast canceres
dc.subjectPolymorphismses
dc.subjectMicroRNAes
dc.subjectSouth American populationes
dc.titleGenetic Variants in pre-miR-146a, pre-miR-499, pre-miR-125a, pre-miR-605, and pri-miR-182 Are Associated with Breast Cancer Susceptibility in a South American Populationes
dc.typeArticlees

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